The lancet oncology
-
The lancet oncology · Jun 2017
Multicenter StudyAdenoma surveillance and colorectal cancer incidence: a retrospective, multicentre, cohort study.
Removal of adenomas reduces colorectal cancer incidence and mortality; however, the benefit of surveillance colonoscopy on colorectal cancer risk remains unclear. We examined heterogeneity in colorectal cancer incidence in intermediate-risk patients and the effect of surveillance on colorectal cancer incidence. ⋯ National Institute for Health Research Health Technology Assessment, Cancer Research UK.
-
The lancet oncology · Jun 2017
ReviewEvolving adoptive cellular therapies in urological malignancies.
Immunotherapies have long been used to treat urological cancers but rarely lead to cure. In the past 5 years, success of immune checkpoint inhibition has led to a resurgence of enthusiasm for immunotherapy in the treatment of solid tumours. ⋯ In this Review, we present the results of clinical studies investigating autologous cellular therapies in urological malignancies. Specifically, we discuss the rationale for upcoming studies, and how novel therapies and adoptive cell combinations can be used for personalised cancer therapy.
-
The lancet oncology · Jun 2017
Treatment of metastatic uveal melanoma with adoptive transfer of tumour-infiltrating lymphocytes: a single-centre, two-stage, single-arm, phase 2 study.
Uveal melanoma is a rare tumour with no established treatments once metastases develop. Although a variety of immune-based therapies have shown efficacy in metastatic cutaneous melanoma, their use in ocular variants has been disappointing. Recently, adoptive T-cell therapy has shown salvage responses in multiple refractory solid tumours. Thus, we sought to determine if adoptive transfer of autologous tumour-infiltrating lymphocytes (TILs) could mediate regression of metastatic uveal melanoma. ⋯ Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research.
-
The lancet oncology · Jun 2017
International incidence of childhood cancer, 2001-10: a population-based registry study.
Cancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer incidence in the past two decades are scarce. This study aimed to provide internationally comparable local data on the incidence of childhood cancer to promote research of causes and implementation of childhood cancer control. ⋯ International Agency for Research on Cancer and the Union for International Cancer Control.