ANZ journal of surgery
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ANZ journal of surgery · Jun 2015
Randomized Controlled TrialEffect of intravenous lignocaine on perioperative stress response and post-surgical ileus in elective open abdominal surgeries: a double-blind randomized controlled trial.
Perioperative stress response can be detrimental if excessive and prolonged. Intravenous (i.v.) lignocaine, while being an effective analgesic, has the added benefit of anti-inflammatory activity. This study was done to assess the effect of i.v. lignocaine on operative stress response and post-surgical ileus after elective open abdominal surgeries. ⋯ Perioperative i.v. lignocaine infusion attenuates the operative stress response, provides effective analgesia and reduces the need for opioids post-operatively. Through these effects, it reduces post-operative ileus and the incidence of PONV.
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ANZ journal of surgery · Jun 2015
Randomized Controlled Trial Comparative StudyPre-emptive epidural analgesia improves post-operative pain and immune function in patients undergoing thoracotomy.
Pre-emptive analgesia may relieve post-operative pain. However, its effects on immune function of patients undergoing thoracotomy are still unclear. Therefore, we investigated effects of pre-emptive epidural analgesia on post-operative pain and immune function in patients undergoing thoracotomy. ⋯ These findings suggest that pre-emptive epidural analgesia can produce better analgesia effects, with less analgesic demands and side effects, and attenuate the surgery-induced immune alterations, and improve the post-operative recovery in patients undergoing thoracotomy.