Clinical medicine (London, England)
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Cardiovascular disease (CVD) remains one of the principal causes of morbidity and mortality in the world. International guidelines are being updated to take into account new evidence and improved health economics as drug patents expire. Recent studies have investigated the best lipid fractions to predict CVD, suggested additional CVD risk factors and a potential role for novel biomarkers while big data approaches have allowed improvements to be made to CVD risk calculators. ⋯ New data has been published on novel lipid-lowering therapies such as proprotein convertase subtilisin kexin 9 inhibitors but the role of these expensive drugs has yet to be fully settled and a diversity of approaches exists between guidelines. The role of lipid fractions outside LDL-C is unclear. There will be challenges in incorporating new non-linear data on omega-3 fatty acids that not only affect triglycerides but more directly CVD.
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The UK National Institute for Health and Care Excellence (NICE) updated its guidelines on stable chest pain in 2016 and recommended computed tomography coronary angiography (CTCA) as first line investigation for all patients with new onset symptoms. We implemented the guideline and audited downstream testing. ⋯ CTCA was an effective rule-out test for most patients. In patients that went on to have ICA, the overall yield of severe CAD was relatively high. This compares well with our previous audit applying the NICE 2010 guidelines which recommended ICA for all high probability patients wherein the yield of severe CAD was 30%.
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Isolated aortic infection is rare and is typically associated with an underlying aortic aneurysm or a prosthetic aortic graft. ⋯ This is an unusual case of acute upper limb ischaemia due to a mass infected with Citrobacter koseri in the ascending aorta without heart valve involvement.
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We aimed to describe and evaluate the National Early Warning Score (NEWS) in the 24 hours preceding an in-hospital cardiac arrest among general somatic ward patients. The 24 hours preceding the in-hospital cardiac arrest were divided into four timespans and analysed by a medical record review of 127:254 matched case-control patients. ⋯ The NEWS high-risk category was associated with an increase of 3.17 (95% confidence interval (CI) 1.66-6.04) to 4.43 (95% CI 2.56-7.67) in odds of in-hospital cardiac arrest compared to the low-risk category. NEWS, with its intuitive and for healthcare staff easy to interpret risk classification, is suitable for discriminating deteriorating patients with major deviating vital signs scoring high risk on NEWS.