Internal medicine journal
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Internal medicine journal · Jul 2020
Randomized Controlled TrialModel-based analysis on systemic availability of co-administered cannabinoids after controlled vaporised administration.
The most important two medicinal cannabinoids are Δ9 -tetrahydrocannabinol (THC) and cannabidiol (CBD). Vaporised administration is superior due to its higher systemic availability, lower individual variability and faster drug delivery. Although it is common THC is co-administered with CBD, the influence of CBD on the pharmacokinetics, especially the systemic availability of THC after vaporised administration, is unknown. ⋯ The results observed in this study are useful for guiding future pharmacokinetic studies of medicinal cannabinoids, and for development of dosing guidelines for medical use of cannabis in the 'real-world' setting.
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Internal medicine journal · Jul 2020
Observational StudyLupus nephritis in Indigenous Australians: a single-centre study.
The incidence, presentation and outcomes of lupus nephritis (LN) vary with geography, ethnicity, socioeconomic status and gender. There are relatively few data on LN in the non-Caucasian populations in Australia. ⋯ The clinical presentation of LN in Aboriginal and Torres Strait Islanders in Far North Queensland is severe and the response to standard immunosuppressive therapy is unsatisfactory. Larger prospective multi-centre studies are required to better understand ethnic disparities in prognosis and response to immunosuppressive therapy in this specific population.
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Internal medicine journal · Jul 2020
Case ReportsLeft anterior descending artery dissection: a rare sequela of blunt chest trauma.
Traumatic coronary artery (CA) dissection is an extremely rare sequela of blunt chest trauma. Diagnosis of CA dissection in the setting of chest trauma is challenging. ⋯ The ideal treatment modality for managing CA dissection has not been established with case reports revealing a range of treatment strategies ranging from CA bypass grafting to a completely conservative management. Here we present a case report of a 68-year-old man who suffered a traumatic proximal left anterior descending artery dissection as a consequence of a motor-vehicle accident and was subsequently treated with a combination of conservative and interventional strategy with optimal patient outcome.
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Internal medicine journal · Jul 2020
Patients with multiple myeloma over a large catchment of 2.5 million square kilometres: a Western Australia retrospective survival review.
Multiple myeloma is an incurable malignancy of plasma cells. We retrospectively reviewed the survival outcomes of patients with multiple myeloma in Western Australia (WA) public hospitals over a 10-year period. We did not detect a difference in survival between patients residing the metropolitan Perth and regional areas, despite a paucity of haematology services in regional WA due to low population density in a large geographic area. Patients with R-ISS Stage 3 had the poorest survival in our cohort with median survival of 24 months.
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Internal medicine journal · Jul 2020
Comparison of the effects of oral iron treatment every day and every other day in female patients with iron deficiency anaemia.
It is known that daily divided doses and high doses of iron increase hepcidin and reduce iron absorption. ⋯ A low-dosage of iron treatment every other day may be used in the place of providing iron once or twice every day with similar effectiveness and lower rates of GIS side effects.