Internal medicine journal
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Internal medicine journal · Apr 2023
ReviewFrailty in chronic kidney disease: challenges in nephrology practice. A review of the current literature.
Frailty is a multidimensional clinical syndrome characterised by low physical activity, reduced strength, accumulation of multi-organ deficits, decreased physiological reserve and vulnerability to stressors. Frailty pathogenesis and 'inflammageing' is augmented by uraemia, leading to a high prevalence of frailty potentially contributing to adverse outcomes in patients with advanced chronic kidney disease (CKD), including end-stage kidney disease (ESKD). ⋯ Frailty assessment should form part of routine assessment of patients with CKD and inform key medical transitions. Frailty screening and interventions in CKD/ESKD should be a research priority.
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Internal medicine journal · Apr 2023
ReviewSudden cardiac death related to physical exercise in the young: a nationwide cohort study of Australia.
Sudden cardiac death (SCD) during physical exercise is devastating. ⋯ The present study demonstrates the high occurrence of CAD and SADS in SCD in the young related to physical exercise. Aboriginal and Torres Strait Islanders were disproportionately affected by CAD. Although events were commonly witnessed, AED was seldom used prior to ambulance arrival and highlights an important opportunity to improve outcomes in the post-arrest chain of survival.