Internal medicine journal
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Internal medicine journal · Jul 2023
Prognostic significance of 24-hour Blood Pressure and Variability Indices in the Outcome of Acute Ischemic Stroke.
The association between blood pressure (BP) levels and BP variability (BPV) following acute ischaemic stroke (AIS) and outcome remains controversial. ⋯ In contrast with BPV indices, ABPM-derived BP levels and lower or absence of BP nocturnal decline in the acute phase are prognostic factors of outcome in AIS patients.
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Internal medicine journal · Jul 2023
Renal physiology and kidney injury during intense (CrossFit®) exercise.
High-intensity training (HIT) programmes are popularly associated with improvements in exercise efficiency and body composition, although, at extremes, have been accompanied by concerns of secondary rhabdomyolysis and severe acute kidney injury (AKI). Beyond the anecdotal, robust literature on the physiological impact of HIT on renal function is currently limited. ⋯ Intense (CrossFit®) exercise is associated with significant metabolic demands and alterations in parameters of renal physiology and function. The observed rise in both conventional and novel biomarkers of renal function following the workout Macho Man specifically might indicate a degree of transient subclinical functional impairment with CrossFit®-type training.
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Internal medicine journal · Jul 2023
A retrospective review of Immunology patients with primary and/or secondary immunodeficiency, demonstrating the benefits of the rapid transitioning from intravenous immunoglobulin to subcutaneous immunoglobulin at the onset of the Covid-19 pandemic.
Forty-four of 50 immunology patients with primary or secondary immunodeficiency receiving intravenous immunoglobulin at a hospital in New South Wales, Australia, were rapidly enrolled in the subcutaneous immunoglobulin (SCIg) programme at the onset of the 2020 COVID-19 pandemic. Health and economic outcomes demonstrated that SCIg provides clinical efficacy as evidenced by the number of infections and maintenance of IgG levels, and also facilitates cost reduction in immunoglobulin maintenance programmes.
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Internal medicine journal · Jul 2023
Osmotic demyelination syndrome: novel risk factors and proposed pathophysiology.
Osmotic demyelination syndrome (ODS) is non-inflammatory demyelination in response to an osmotic challenge. It can be pontine or extrapontine in presentation. ⋯ We found that ODS occurred despite appropriate correction rates of hyponatraemia. Factors such as malnutrition, chronic alcoholism, hypokalaemia and hypophosphataemia are thought to play a role in its pathogenesis. Approximately half of the patients survived and became functionally independent.