Internal medicine journal
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Internal medicine journal · May 2002
ReviewCentral nervous system prophylaxis in haematological malignancies.
Given the poor prognosis of central nervous system (CNS) involvement in haematological malignancies, management is directed towards prevention. CNS prophylaxis may take the form of intrathecal therapy, cranial irradiation, systemic therapy or some combination of these. The toxicity of these methods is an important consideration. A risk-orientated approach to the delivery of CNS prophylaxis in each disorder is required.
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Internal medicine journal · May 2002
Letter Case ReportsFailure of montelukast to prevent aspirin-induced asthma.
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Internal medicine journal · Apr 2002
Comparative StudyBenchmarking ambulance call-to-needle times for thrombolysis after acute myocardial infarction in Australia: a pilot study.
Thrombolysis for patients with acute myocardial infarction (AMI) is of greatest benefit when treatment is commenced as soon as possible after symptom onset. The British Heart Foundation (BHF) recently set a benchmark recommending that eligible patients with AMI receive thrombolytic therapy less than 90 min after calling for medical assistance. ⋯ This study showed that the BHF benchmark for CTN was not being met for over one-third of patients in the study region, with potential impact on mortality after AMI. Further research is needed to establish: (i) whether there is relationship between longer transportation times and mortality, (ii) whether the findings of this study may be applied to other regions and (iii) what strategies might be employed to reduce CTN.