Internal medicine journal
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Internal medicine journal · Oct 2023
Clinical associations of patients with anti-3-hydroxy-3-methylglutaryl CoA reductase antibody associated immune-mediated necrotising myopathy.
Anti-3-hydroxy-3-methylglutaryl CoA reductase (HMGCR) antibodies are associated with a subtype of immune-mediated necrotising myopathy (IMNM). ⋯ The PPV of anti-HMGCR antibodies for HMGCR-IMNM in this Western Australian cohort is 88%. Patients typically present with proximal limb weakness, dysphagia and markedly elevated CK, and, despite multiagent immunosuppression, a significant number of patients have evidence of persistent biochemical myositis. Anti-HMGCR antibodies did not correlate with CK levels at diagnosis.
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Internal medicine journal · Oct 2023
Observational StudyCharacterising Patients and Clinician Experiences in Comprehensive Conservative Care for Kidney Failure in Northern Queensland.
Comprehensive conservative care (CCC) is an emerging treatment option in kidney failure (KF), but its implementation has been restricted by a limited understanding of KF populations, outcomes and clinician experiences. ⋯ Patients who are highly co-morbid and frail and have functional impairment are suitable candidates for CCC. More focus needs to be placed on objective prognostication of patients and the upskilling of clinicians to advocate for, and deliver, CCC.