Best practice & research. Clinical anaesthesiology
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Do patients form memories of intra-operative events when they are adequately anaesthetized? Studies of memory priming during anaesthesia with depth or awareness monitoring provide some evidence that they do, although only the most basic form of memory function, perceptual priming, persists when patients are unconscious. The probability of memory encoding increases as depth of anaesthesia decreases. There is a theoretical possibility that patients can be adversely affected, through memory priming, by comments made in the operating theatre, and some evidence that positive intra-operative suggestions can benefit patients.
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Inadequate anaesthesia may lead to awareness. A properly trained anaesthetist, administering anaesthesia according to their knowledge of pharmacology and patient and surgical characteristics, assisted by clinical signs and monitoring, can minimize this risk. Relying upon volatile-based anaesthesia delivered at a concentration of at least 0.5 MAC may be effective, but this precludes the use of total intravenous anaesthesia techniques and in any case may lead to unwanted hypotension. ⋯ The development of electroencephalographic monitors of anaesthetic depth provides an opportunity to prevent awareness. Two large scale studies, one of which was a randomized trial, have identified a 5-fold reduction in risk of awareness when depth of anaesthesia using bispectral index monitoring was used. The incidence of awareness can be further reduced with currently available techniques used more widely.
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Best Pract Res Clin Anaesthesiol · Sep 2007
Awareness, dreaming and unconscious memory formation during anaesthesia in children.
Recent studies have reported an incidence of awareness in children of around 1%, while older studies reported incidences varying from 0% to 5%. Measuring awareness in children requires techniques specifically adapted to a child's cognitive development and variations in incidence may be partly explained by the measures used. The causes and consequences of awareness in children remain poorly defined, though a consistent finding is that many children do not seem distressed by their memories. ⋯ Compared to explicit memory, implicit memory is more robust in young children; however there is no evidence yet for implicit memory formation during anaesthesia in children. Children less than 3 years of age do not form explicit memory, although toddlers, infants and even neonates have signs of consciousness and implicit memory formation. In these very young children the relevance of awareness remains largely unknown.
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Best Pract Res Clin Anaesthesiol · Sep 2007
Monitoring consciousness: the current status of EEG-based depth of anaesthesia monitors.
Direct and indirect inhibitory effects of anaesthetic agents on cortical activity are reflected in the electroencephalogram (EEG) as: (i) a shift from low-amplitude, high-frequency EEG, to high-amplitude, low-frequency activity (indicative of cortical depowering) and; (ii) the appearance of spindles and K-complexes (indicative of thalamocortical hyperpolarisation and sensory blockade). Existing EEG monitors use cortical activity as a proxy measure for consciousness. ⋯ Also the literature reveals many instances where the EEG pattern is dissociated from conscious state (e.g. an awake-looking EEG, but an unresponsive patient; or a slow-wave EEG in an awake patient). Fortunately, a slow-wave EEG (even in the presence of a responsive patient) usually indicates profound amnesia for explicit memory.
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Best Pract Res Clin Anaesthesiol · Sep 2007
Incidence of and risk factors for awareness during anaesthesia.
Explicit recall of events during general anaesthesia is detected by direct questioning, as patients may not report awareness spontaneously or if they are questioned non-specifically. More than one interview is needed and credibility of reports should always be verified. ⋯ Studies of patients recruited through referrals by colleagues or advertisements, studies of compensation claims and those carried out through quality improvement systems are inadequate. Several factors increase the risk of awareness, including light anaesthesia, some types of surgery, a history of awareness, chronic use of central nervous system depressants, younger age, obesity, inadequate or misused anaesthesia delivery systems, insufficient knowledge about awareness, and ignoring the use of electroencephalographic monitors when the risk is otherwise increased.