Journal of pain & palliative care pharmacotherapy
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J Pain Palliat Care Pharmacother · Jun 2010
The Food and Drug Administration risk evaluation and mitigation strategy.
The Food and Drug Administration Amendments Act of 2007 extended the agency's regulatory authority over drug products that have been shown to place patients at risk. This Act authorizes the FDA to require pharmaceutical manufacturers and distributors to ensure that the safety of their products continue to outweigh the risks. This article discusses in more detail the proposed elements of an acceptable Risk Evaluation and Mitigation Strategy (REMS) for any drug product, including extended-release opioid analgesics.
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J Pain Palliat Care Pharmacother · Mar 2010
Evidence-based pain management and palliative care in issue four for 2009 of The Cochrane Library.
The Cochrane Library of Systematic Reviews is published quarterly. Issue 4 for 2009 contains 4027 complete reviews, 1906 protocols for reviews in production, and 11447 one-page summaries of systematic reviews published in the general medical literature. ⋯ The health technology assessment database contains over 7500 citations. This edition of the Library contains 90 new reviews, of which 19 have potential relevance for practitioners in pain and palliative medicine.
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J Pain Palliat Care Pharmacother · Mar 2010
Internet resources on managing chronic nonmalignant pain with opioids: the risks of addiction.
Chronic nonmalignant pain affects approximately 20% of the population. Internet resources for management of chronic pain have expanded in response to this growing population of chronic nonmalignant pain patients. ⋯ Discontinuation of opioid therapy needs to be adequately and appropriately addressed in patients with aberrant behavior and treated. This includes proper screening and monitoring and the use of emerging agents that will effectively control pain and are associated with a lower risk of abuse.