Journal of pain & palliative care pharmacotherapy
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J Pain Palliat Care Pharmacother · Jun 2014
Clinical TrialA transit compartment model unmasks OxyContin's reflective pharmacokinetics from urine measurements in humans.
The absorption pattern of orally administered OxyContin (OXC) reflected in urine indicates that its appearance into systemic circulation undergoes transit absorption delays. The authors developed an OXC transit-delay compartment model that identified a new source of oxycodone hydrochloride (OC): the rate of appearance of OC due to OXC tablet dissolution in transit through the gastrointestinal (GI) tract (R(a)(GI)), which is due to disintegration of OXC's AcroContin delivery system. R(a)(GI) is independent of the biphasic dissolution and release of OC from the delivery system. The authors conclude that an OXC transit-delay compartment model can be of value in the interpretation of OXC pharmacokinetics.
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J Pain Palliat Care Pharmacother · Jun 2014
Case ReportsPain management discussion forum: serious interaction among frequently used drugs for chronic pain.
A query and response regarding a patient who was taking high-dose tramadol and duloxetine is presented. The patient developed serotonin syndrome. Risks for this clinically important drug interaction and management of the syndrome are discussed.
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Human animals have evolved with the primary missions of survival and reproduction and these natural drives may impact behavior whether humans are aware of them or not. The author offers evidence in support of the idea that injury and resulting acute or chronic pain may trigger the unconscious human primate brain to believe there is a threat to survival. This perceived threat may be exacerbated or mitigated by the pain manager, both of which may impact health outcomes in a negative or positive way, respectively. The commentary argues the patient-health care provider relationship is of paramount importance for those with chronic pain and illness and should be nurtured for the best possible outcomes.
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The results of a survey conducted by the pan-European Opioids and Pain European Network of Minds (OPENMinds) Primary Care Group (OMPC) on pain assessment, opioid therapy, and educational needs are presented.
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J Pain Palliat Care Pharmacother · Jun 2014
Strengthening of palliative care as a component of integrated treatment throughout the life course.
In December 2013, the World Health Organization Executive Board generated a report entitled: Strengthening of palliative care as a component of integrated treatment throughout the life course. The contents of that report are presented.