The Lancet infectious diseases
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Review Case Reports
Subdural empyema and other suppurative complications of paranasal sinusitis.
Suppurative intracranial infection, including meningitis, intracranial abscess, subdural empyema, epidural abscess, cavernous sinus thrombosis, and thrombosis of other dural sinuses, are uncommon sequelae of paranasal sinusitis. A high index of suspicion is necessary to identify these serious complications. We present a patient with subdural empyema in whom the diagnosis was delayed, followed by a discussion of suppurative complications of sinusitis. The case shows the rapid progression of subdural empyema, which represents a true neurosurgical emergency requiring prompt diagnosis and management.
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Childhood pneumonia and diarrhoeal disease cause almost half of all child deaths globally. Effective interventions against these conditions are available and could prevent about two-thirds of these deaths. ⋯ We present a novel research priority setting model that shifts the emphasis from generation of new knowledge and publication to potential public-health outcomes, and propose a framework by which this new model can be put into operation. We believe that only in this way will proper attention be given to delivery of proven interventions to reduce the high childhood mortality caused by pneumonia and diarrhoea.