The spine journal : official journal of the North American Spine Society
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The use of nonsteroidal anti-inflammatory drugs (NSAIDs) had been implicated as a risk factor for nonunion in spinal fusion. Even with a number of animal and human studies suggesting NSAIDs either delay or inhibit spinal fusion rates, these drugs continue to be used because of demonstrated benefits. Diclofenac sodium is no exception. It is very popular as a first-line treatment for acute pain, even perioperatively for spine fusion patients. Review of published literature reveals no studies done on the effect of diclofenac sodium on spine fusion rates. ⋯ Diclofenac sodium showed a dose-dependent inhibitory effect toward spine fusion especially when used during the immediate postoperative period. No significant correlation was seen between age, sex, L5-S1 versus other levels fused and smoking history when compared with spine nonunion. Two-level lumbar fusions also showed a significant negative correlation to spine fusion compared with single-level fusions.
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Hemangioblastomas in the central nervous system are highly vascular lesions, but have low risk of hemorrhage. In spinal lesions, there are a few rare cases of intramedullary hemorrhages associated with hemangioblastoma, and their prognoses were very severe. ⋯ We present this rare case, and emphasize hemangioblastoma as the differential diagnosis in hemorrhagic spinal lesion.
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Ten percent of patients with low back pain (LBP) are not able to resume work within 3 months of sick leave, accounting for 90% of all medical and indemnity costs. ⋯ A questionnaire comprising a limited set of items allows a practical screening of LBP patients unlikely to resume work.
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Achieving solid implant fixation to osteoporotic bone presents a clinical challenge. New techniques and devices are being designed to increase screw-bone purchase of pedicle screws in the lumbar spine via a novel cortical bone trajectory that may improve holding screw strength and minimize loosening. Preliminary clinical evidence suggests that this new trajectory provides screw interference that is equivalent to the more traditionally directed trajectory for lumbar pedicle screws. However, a biomechanical study has not been performed to substantiate the early clinical results. ⋯ The current study demonstrated that the new cortical trajectory and screw design have equivalent pullout and toggle characteristics compared with the traditional trajectory pedicle screw, thus confirming preliminary clinical evidence. The 30% increase in failure load of the cortical trajectory screw in uniaxial pullout and its juxtaposition to higher quality bone justify its use in patients with poor trabecular bone quality.