The spine journal : official journal of the North American Spine Society
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Adolescent idiopathic scoliosis (AIS) affects 2% to 4% of the population and predominantly affects female individuals. The scoliosis researchers and clinical communities use the "Cobb angle" obtained from anterior-posterior radiographs as the standard assessment tool for scoliosis. However, excessive radiation exposure over consecutive visits during the growing years increases the risk of cancer in young patients with AIS. Surface topography (ST) is a noninvasive method that is being investigated as an alternative tool for scoliosis assessment. The necessity of applying markers by skilled operators, which is time consuming and a potential area for errors, is one of the main limitations of these methods. ⋯ A novel method to examine torso asymmetry in patients with AIS is presented, using noninvasive ST scans and a visually intuitive asymmetry map. Distinct patterns of asymmetry were identified allowing patients to be classified into three groups, with six subgroups based on their asymmetry map with very good to excellent reliability. The presented technique shows promise to provide a noninvasive tool for assessment and monitoring of AIS.
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Nonsurgical rehabilitation therapy is a commonly used strategy to treat chronic low back pain (LBP). The selection of the most appropriate therapeutic options is still a big challenge in clinical practices. Surface electromyography (sEMG) topography has been proposed to be an objective assessment of LBP rehabilitation. The quantitative analysis of dynamic sEMG would provide an objective tool of prognosis for LBP rehabilitation. ⋯ The quantitative time-varying analysis of sEMG topography showed significant difference between the healthy and LBP groups. The discrepancies in quantitative dynamic sEMG topography of LBP group from normal group, in terms of RA and RW of RMSD at flexion and extension, were able to identify those LBP subjects who would respond to a conservative rehabilitation program focused on functional restoration of lumbar muscle.
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Denosumab (XGeva) is a receptor activator of nuclear factor-κB ligand (RANKL)-antibody that was approved by the Food and Drug Administration (FDA) in 2010 for the prevention of skeletal fractures in patients with bone metastases from solid tumors. Although there is a widespread use of such drug in patients under risk of pathological fractures, the compatibility of denosumab therapy with percutaneous vertebroplasty (an interventional procedure commonly used for pain control in such population) has not yet been established. ⋯ This is the first report of the technical peculiarities of percutaneous vertebroplasty in patients under medical treatment with denosumab. According to our experience, because of its RANKL-mediated effects on osteoclasts activity, denosumab has been shown to induce a fast and marked sclerotic response on vertebral bodies that may not be accompanied by a satisfactory improvement in pain control (especially in patients with mechanical type of pain) and which may actually prevent the successful performance of percutaneous vertebroplasty. Therefore, it is of paramount importance that future studies evaluating patients with vertebral fractures under treatment with denosumab include long-term pain outcome measures. Additionally, further investigation is warranted to determine the optimal order of treatment and the best timeframe for combining percutaneous vertebroplasty and denosumab therapy in patients presenting with acute vertebral compression fractures and refractory axial pain.
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In patients affected by cervical spondylotic myelopathy (CSM), numerous authors have reported the existence of a relationship among the intramedullary high signal intensity in T2-weighted MRIs, preoperative neurologic severity, and neurologic recovery after surgery; however, to our knowledge, there have been no previous reports that have described its relationship in patients with atlanto-axial subluxation (AAS) owing to rheumatoid arthritis (RA). ⋯ Preoperative ISHI in T2-weighted MRIs in RA-induced AAS patients was demonstrated in patients showing an enlargement of the ADD and a narrowing of the SAC. This affected the preoperative neurologic severity, but not the postoperative severity, which was in contrast to CSM patients. Furthermore, the regression or disappearance of ISHI was demonstrated in all of the cases after surgery. It is therefore speculated that RA AAS patients may have both dynamic instability and stenosis.
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Postoperative paresis, so-called C5 palsy, of the upper extremities is a common complication of cervical surgery. There have been several reports about upper extremity palsy after cervical laminoplasty for patients with cervical myelopathy. However, the possible risk factors remain unclear. ⋯ Patients with preoperative foraminal stenosis, OPLL, and additional iatrogenic foraminal stenosis because of CLP+PIF were more likely to develop postoperative upper extremity palsy. Attention should be given to the WIF determined on preoperative computed tomography of the C5 root. To prevent iatrogenic foraminal stenosis, appropriate distraction between spine segments should be provided during placement of the rod.