Latest Articles
-
The management of chronic non-cancer pain (CNCP) is complex. Concerns about adverse effects associated with opioid pain medications and a lack of funding for holistic programs present challenges for decision-making among clinicians and patients. Discrete choice experiments (DCE) are one way of assessing and valuing patient treatment preferences. ⋯ A discrete choice experiment identified two groups: younger, with more private insurance, and older, with less private health insurance, each with unique pain management preferences. Clinicians should be aware that age and private health insurance may have an impact on a patient's preferences for CNCP management.
-
Autoimmune encephalitides (AE) constitute a broad group of inflammatory brain disorders characterized by prominent neuropsychiatric symptoms, frequently in association with autoantibodies against neural (neuronal or glial) antigens. The most frequent AE are anti-NMDA receptor encephalitis, acute disseminated encephalomyelitis (associated with MOG antibodies in 60% of patients), and limbic encephalitis (with several immunologic subtypes, anti-LGI1 encephalitis being the most frequent). The first 2 predominantly affect children and young adults, whereas limbic encephalitis usually affects patients older than 50 years. Despite the severity of symptoms, prompt diagnosis and treatment lead to substantial recovery in most patients.
-
Tobacco use is known to affect incidence and postoperative outcome for several neurosurgical disorders, but its relationship to trigeminal neuralgia (TN) is not known. We sought to identify unique population characteristics that correlate with tobacco use in a cohort of patients with TN who underwent microvascular decompression (MVD), including effect on long-term postoperative outcome. ⋯ In patients undergoing MVD for TN, smoking is associated with younger age of TN onset, more widespread facial pain, and worse long-term postoperative outcome after MVD. These features suggest that TN in smokers may represent a more severe disease form compared with TN in nonsmokers with different responses to treatment.
-
While pharyngitis is a common primary care complaint, evidence reveals that this diagnosis is an area where antibiotic therapy is frequently misused. Appropriate diagnosis and management of pharyngitis is crucial to ensure antimicrobial stewardship and improve patient safety and outcomes. Pharyngitis etiologies include both infectious and noninfectious sources such as bacteria, viruses, fungal organisms, trauma, irritants, laryngopharyngeal reflux, and medications. Clinicians need to obtain a thorough history and careful physical examination, along with appropriate diagnostic testing when indicated, to ensure treatment plans are targeted toward the most likely pharyngitis etiology.
-
Med. Clin. North Am. · Mar 2025
ReviewSecondary Risk Reduction after Transient Ischemic Attack and Minor Stroke.
This article discusses the evolving definitions of transient ischemic attack and minor strokes, highlighting the shared risk factors and the similarities in approach and early management. It emphasizes the importance of early identification and basic workup for these patients, as well as the most effective early antithrombotic therapies to date. The article also emphasizes the significance of controlling risk factors and concludes with a discussion of treatment strategies based on specific stroke etiologies.