Articles: analgesics.
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Br J Obstet Gynaecol · Jun 1983
Comparative Study Clinical Trial Controlled Clinical TrialMenstrual blood loss in dysmenorrhoea: effects of proquazone and indomethacin.
Abnormal production of uterine prostaglandins (PG) causes primary dysmenorrhoea and excessive menstrual blood loss (MBL). We measured here MBL in primary dysmenorrhoea and found it to be normal during treatment with opiate analgesics (33.5 +/- 21.6 ml; mean +/- SD. n = 13), placebo (33.4 +/- 18.6 ml; n = 8), proquazone (31.8 +/- 18.0 ml; n = 8) and indomethacin (26.4 +/- 18.7 ml; n = 8). Proquazone and indomethacin relieved pain and other dysmenorrhoeic symptoms similarly in 33 women.
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The haemodynamic and respiratory-depressive effects of 20 micrograms/kg and 40 micrograms/kg of alfentanil in 54 patients with coronary bypass operation were compared with a control group (n = 36). The measurements were carried out at 3 different times, each lasting over a 10 min period: 1. Before induction of anaesthesia but after premedication with flunitrazepam. 2. ⋯ In the intraoperative period this did not occur. The respiratory depression(paO2: -34%, paCO2: +29%) resembles that after fentanyl, except that it starts earlier and lasts for a shorter time. In summary, it can be stated that all effects after alfentanil are similar to those of fentanyl.
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison of flupirtine maleate and dihydrocodeine in patients following surgery.
Flupirtine maleate 100 mg was compared with dihydrocodeine 60 mg when given by mouth to 50 women on the first 3 days following abdominal hysterectomy in a double-blind parallel-group trial. The analgesia produced was similar for both preparations, and the consumption of active drug was the same in both groups. The only significant differences in side-effects were an increased frequency of depression in patients receiving flupirtine and of sleepiness in those receiving dihydrocodeine.
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Postgraduate medicine · May 1983
Chronic pain. A pharmacologic review and behavior modification approach.
Management of pain syndromes clearly requires a multidimensional approach and involves social, psychologic, and somatic factors. At the Behavioral Medicine/Pain Therapy Center of Jewish Hospital, St Louis, most patients significantly increase social and physical activity using the combined approach outlined. A majority of patients previously treated with complicated drug regimens do well on little or no medicine. When medications are required for long-term treatment, tricyclic antidepressants have been most successful.
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A radiological study was made in 33 patients of the position of the epidural catheter and the spread of the contrast medium Metrizamide (Amipaque) when used in volumes of 10, 15 and 20 ml. The puncture at the interspinal space L2/L3 and L3/L4 allows the safe inclusion of eight peridural segments in all cases, whereas puncture of the upper regions of the spine results in a less predictable effect with spread of the injected fluid to higher spinal segments. A larger volume of contrast medium of 15 ml allows the safe inclusion of a larger number of spinal segments. Abnormal presentation, areas of fluid loss and the distribution of the analgesics or local anaesthetics injected may be detected early, which allows correction or adaptation of decisions concerning the fluid volume or the concentration of analgesics such as morphine.