Articles: mechanical-ventilation.
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The aim of this study was to define the level of peak inspiratory pressure (PIP) and mean airway pressure ([Formula: see text]) at which a pneumothorax is produced in an in vivo ARDS neonate model. In addition, we analyzed the hemodynamic response and cerebral parameters during the progressive increase of intrathoracic pressure. ⋯ A progressive increase of PEEP at a constant driving pressure did not increase severe adverse events at the range of pressures that we routinely use in neonates with ARDS. Asystole, pneumothorax, and cerebral compromise appeared at high intrathoracic ranges of pressure. Hemodynamics must be strictly monitored in all patients during the performance of lung recruitment maneuvers because hemodynamic deflections emerge early, at a range of pressures commonly used in ventilated neonates with ARDS.
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Pediatr Crit Care Me · Oct 2022
The Relevance of Airway Resistance in Children Requiring Mechanical Ventilatory Support.
To describe pulmonary resistance in children undergoing invasive mechanical ventilation (MV) for different causes. ⋯ Increased pulmonary resistance is prevalent in the pediatric population undergoing invasive MV. Especially in children less than 1 year old, this variable should be considered when defining a ventilatory strategy.
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Little is known about the fate of expelled viral particulates during the aerosolization of inhaled medications during mechanical ventilation. We hypothesized that breathing patterns that generate a greater degree of shear stress and turbulent air flow will produce a greater concentration of exhaled viral RNA with the presence of a nebulizer during mechanical ventilation. ⋯ In this ex vivo porcine model, the introduction of a nebulizer did not increase the mean viral RNA captured throughout all of the breathing patterns.
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Editorial Comment
Intraoperative Protective Mechanical Ventilation: Fact or Fiction?