Articles: analgesia.
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Int J Obstet Anesth · Jan 1995
Backache and epidural analgesia: a retrospective survey of mothers 1 year after childbirth.
A questionnaire was sent to 2065 mothers 1 year after delivery as part of a larger study into patient satisfaction with all aspects of their obstetric care. The response rate adjusted for non-delivered mail was 67.1%. There was a high incidence of new long-term backache in mothers who had received epidural analgesia (26.2% at one year) compared to the mothers who had not (1.7%). Further analysis of the data revealed no other significant associated factor.
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Subcutaneous injection of dilute formalin in the hind paw of the rat produces a biphasic nociceptive response. Initial C-fiber activity is accompanied by flinching of the paw for about 5 min (phase 1), followed by cessation of activity and resumption of flinching beginning 15 min after injection and lasting about 40 min or more (phase 2). The second phase depends on changes in dorsal horn cell function that occur shortly after the initial C-fiber discharge. It was previously shown that isoflurane, administered during phase 1, reduced phase 2 activity, but a combination of isoflurane and nitrous oxide given throughout phase 1 did not suppress spinal sensitization. The same model was used to determine the effects of several inhalation and intravenous anesthetic agents on phase 2 of the formalin test. ⋯ Volatile anesthetics or nitrous oxide significantly suppress spinal sensitization, whereas the combination of nitrous oxide plus halothane causes no suppression. Thiopental does not affect spinal sensitization, whereas propofol causes significant suppression. These results may have important implications regarding the development of postoperative pain.
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Randomized Controlled Trial Comparative Study Clinical Trial
[The dosage of sedative was reduced by patient-controlled sedation during epidural anesthesia].
The dosage of sedatives required for sedation was studied in patients who underwent total abdominal histerectomy under epidural anesthesia using patient-controlled sedation (PCS) and in those with anesthesiologist-controlled sedation (ACS). Patients in experimental groups received 1.0 or 1.5 mg bolus dose of midazolam by their request until desirable sedation was obtained using a computer-controlled device. ⋯ The level of sedation showed wider variation in PCS groups than in ACS groups. The results suggest that PCS is a technique which allows reduction of sedatives in patients who undergo operation under local anesthesia.
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Cell transplantation · Jan 1995
ReviewRecent topics in the management of pain: development of the concept of preemptive analgesia.
Recent studies concerned with the relationship between injury responses and acute and chronic pain were reviewed. Basic and clinical studies of pain have revealed that a large proportion of the mechanisms that produce strange signs and symptoms, such as allodynia, hyperalgesia and hyperpathia, after tissue injury are ascribed to increased excitability, or to sensitization derived from biological changes in spinal dorsal horn cells subjected to excessive noxious stimuli from injured tissues. ⋯ The findings of many clinical investigations, however, remain controversial. This report discusses the importance of preemptive analgesia including the possibilities of prevention, and of extension to the control, of chronic pain syndromes.
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The neurophysiologic concept of neuroplasticity represents one of the current basis of the pathophysiology of painful post-injury phenomenons (postoperative, post-traumatic...). Deriving directly from these experimental data, the idea of preemptive analgesia has gradually developed in the last five years, the central question being to know if an analgesic intervention preceding surgical intervention is more efficient, as efficient, or less efficient than the same intervention following surgery. The authors bring current data of the literature in favor of the role of neuroplasticity in the genesis and the persistence of painful states in the course of postoperative outcome. A review of the various clinical studies and controversies published is proposed, in the attempt to make the point on current therapeutic implications of the concept of preemptive analgesia.