Articles: pandemics.
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Comparative Study Clinical Trial
Immunogenicity and efficacy in hemodialysis patients of an AS03(A)-adjuvanted vaccine for 2009 pandemic influenza A(H1N1): a nonrandomized trial.
Hemodialysis patients have a reduced response to vaccinations because of uremia-related immune dysfunction. To increase the immunogenicity of vaccines, antigens can be formulated with adjuvants. The new tocopherol-containing adjuvant system AS03(A) has not been tested yet in patients with end-stage renal disease. ⋯ Pandemic H1N1 vaccine adjuvanted with AS03(A) is immunogenic, effective, and safe in hemodialysis patients.
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Critical care medicine · May 2011
Editorial Comment Comparative StudyFrom the bedside to the bench: how to improve the care of critically ill pregnant patients with influenza.
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Systemic safety surveillance is an essential component of vaccination programmes to elucidate the full safety profile of a vaccine and to detect previously unrecognized adverse reactions that might be related to new vaccines. This article summarizes the spontaneous adverse drug reactions (ADR) from approximately 12 million administered doses of the pandemic MF59-adjuvanted H1N1v vaccine (Focetria®, Novartis Vaccines and Diagnostics) from the mass vaccination programmes in Europe. ⋯ The analyses of the spontaneously reported adverse events support the good safety profile of the MF59-adjuvanted H1N1v pandemic influenza vaccine.
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Rev Cubana Med Trop · May 2011
[Molecular diagnosis of influenza A(H1N1) 2009 virus and other respiratory viruses during the first pandemic wave in Cuba].
the first pandemic virus of the 21st century - the influenza A (H1N1)/2009 virus-appeared in Mexico in April 2009 after triple reassortment of influenza strains of avian, human and pig origin and from there, it was spread worldwide. With the purpose of facing up to this event, Cuba adopted antipandemic measures including the virology surveillance using all necessary actions. ⋯ the molecular diagnosis algorithm proved to be sensitive, specific and effective to assure the systematic virological surveillance in our country during the pandemic phase.
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Comparative Study
The impact of the 2009 influenza A(H1N1) pandemic on attitudes of healthcare workers toward seasonal influenza vaccination 2010/11.
The emergence of the influenza A(H1N1)2009 virus provided a major challenge to health services around the world. However, vaccination rates for the public and for healthcare workers (HCWs) have remained low. We performed a study to review the reasons put forward by HCWs to refuse immunisation with the pandemic vaccine in 2009/10 and characterise attitudes in the influenza season 2010/11 due to the emergence of influenza A(H1N1)2009. ⋯ Of the HCWs and students surveyed, 270 of 1,645 (16.4%) stated that the pandemic had influenced their attitude towards vaccination in general. Many German HCWs remained unconvinced of the safety of the pandemic (adjuvanted) influenza vaccine. For this reason, effective risk communication should focus on educating the public and HCWs about influenza vaccine safety and the benefits of vaccination.