Articles: pandemics.
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Health Technol Assess · Dec 2010
Predictive clinicopathological features derived from systematic autopsy examination of patients who died with A/H1N1 influenza infection in the UK 2009-10 pandemic.
From April 2009 to January 2010, the pandemic of A/H1N1 influenza affected the UK. There were > 30,000 infections and 457 deaths (all ages). Reports from other countries had indicated that certain comorbidities were associated with a higher risk of death from H1N1 infection, and there was a need to identify these factors in the UK population as knowledge of them could lead to improved treatment in the current epidemic and reduced mortality in future epidemics. ⋯ The National Institute for Health Research Health Technology Assessment programme.
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Health Technol Assess · Dec 2010
Randomized Controlled Trial Multicenter StudyA randomised, partially observer blind, multicentre, head-to-head comparison of a two-dose regimen of Baxter and GlaxoSmithKline H1N1 pandemic vaccines, administered 21 days apart.
To evaluate the immunogenicity of a two-dose schedule of Baxter cell-cultured, non-adjuvanted, whole-virion H1N1 vaccine, and GlaxoSmithKline AS03(A)-adjuvanted split-virion H1N1 vaccine with respect to the EU Committee for Medicinal Products for Human Use (CHMP) and the US Food and Drug Administration (FDA) licensing criteria. ⋯ AS03(A)-adjuvanted 2009 H1N1 vaccine is more immunogenic and provides greater antigen-sparing capacity than WV 2009 H1N1 vaccine.
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Health Technol Assess · Dec 2010
Multicenter StudyObservational study to investigate vertically acquired passive immunity in babies of mothers vaccinated against H1N1v during pregnancy.
The primary objective was to determine the proportion of babies who acquired passive immunity to A/H1N1v, born to mothers who accepted vaccination as part of the national vaccination programme while pregnant (during the second and/or third trimesters) against the novel A/H1N1v influenza virus (exposed group) compared with unvaccinated (unexposed) mothers. ⋯ The National Institute for Health Research Health Technology Assessment programme.
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Comparative Study
Pandemic H1N1 influenza in the pediatric emergency department: a comparison with previous seasonal influenza outbreaks.
We compare the acuity of pediatric emergency department (ED) patients between the ongoing H1N1 influenza pandemic and previous seasonal influenza outbreaks. ⋯ The severity of illness during the 2009 H1N1 surge appeared similar to that of previous influenza seasons for the total population of the 2 pediatric tertiary care EDs, whereas an increase in the proportion of ICU admissions was observed for patients with influenza-like illness.