Articles: middle-aged.
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Randomized Controlled Trial
Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study.
Lipoprotein(a) (Lp[a]) is a risk factor for cardiovascular disease and calcific aortic valve stenosis. No effective therapies to lower plasma Lp(a) concentrations exist. We have assessed the safety, pharmacokinetics, and pharmacodynamics of ISIS-APO(a)Rx, a second-generation antisense drug designed to reduce the synthesis of apolipoprotein(a) (apo[a]) in the liver. ⋯ Isis Pharmaceuticals.
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To determine benefits and harms of arthroscopic knee surgery involving partial meniscectomy, debridement, or both for middle aged or older patients with knee pain and degenerative knee disease. ⋯ PROSPERO CRD42014009145.
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Suicide is one of the top 10 leading causes of mortality among middle-aged women. Most work in the field emphasizes the psychiatric, psychological, or biological determinants of suicide. ⋯ Women who were socially well integrated had a more than 3-fold lower risk for suicide over 18 years of follow-up.
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The Lancet. Global health · Oct 2015
Mortality risks in children aged 5-14 years in low-income and middle-income countries: a systematic empirical analysis.
Health priorities since the UN Millennium Declaration have focused strongly on children younger than 5 years. The health of older children (age 5-9 years) and younger adolescents (age 10-14 years) has been neglected until recently, especially in low-income and middle-income countries, and mortality measures for these age groups have often been derived from overly flexible models. We report global and regional empirical mortality estimates for children aged 5-14 years in low-income and middle-income countries, and compare them with ones from existing models. ⋯ The Lancet Commission on Investing in Health and the Bill & Melinda Gates Foundation.
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Health Technol Assess · Sep 2015
Randomized Controlled TrialAn open randomised study of autoinflation in 4- to 11-year-old school children with otitis media with effusion in primary care.
Otitis media with effusion (OME) is a very common problem in primary care, but one that lacks an evidence-based non-surgical treatment. ⋯ We found the use of autoinflation in young children with OME to be feasible in primary care and effective in both clearing effusions and improving child and parent ear-related QoL and symptoms. This method has scope to be used more widely. Further research is needed for very young children, and to inform prudent use in different health settings.