Articles: surgery.
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Arch Orthop Trauma Surg · Aug 2024
Review Case ReportsMelorheostosis of the cervical and cervicothoracic spine: review of the literature and presentation of 3 new cases.
Melorheostosis is a rare dysplastic bone disease that usually affects long bones at the upper or lower limbs. It is rarely seen at the spine and very rarely located at the cervical spine. ⋯ Here, we give an overview of the current literature of spinal melorheostosis with respect to number of cases and skeletal distribution, aetiology, radiographic appearance, symptoms and treatment. Finally, we describe 3 new clinical cases with manifestation of melorheostosis at the cervical spine and the cervicothoracic junction.
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Predictors of Delayed Clinical Benefit Following Surgical Treatment for Low Grade Spondylolisthesis.
Retrospective review of prospectively collected data. ⋯ The majority of patients undergoing surgery for low grade spondylolisthesis reach ODI MCID threshold rapidly, within the first three months after surgery. Factors associated with a delayed clinical course include impaired preoperative ambulation status, relatively better preoperative back and leg pain, and persistent leg pain at 3 months.
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Facial grimacing is used to quantify spontaneous pain in mice and other mammals, but scoring relies on humans with different levels of proficiency. Here, we developed a cloud-based software platform called PainFace ( http://painface.net ) that uses machine learning to detect 4 facial action units of the mouse grimace scale (orbitals, nose, ears, whiskers) and score facial grimaces of black-coated C57BL/6 male and female mice on a 0 to 8 scale. ⋯ By analyzing the frequency distribution of grimace scores, we found that mice spent 7x more time in a "high grimace" state following laparotomy surgery relative to sham surgery controls. Our study shows that PainFace reproducibly quantifies facial grimaces indicative of nonevoked spontaneous pain and enables laboratories to standardize and scale-up facial grimace analyses.