Articles: surgery.
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The purpose of the present study was to analyze the outcomes after craniotomies for brain metastases in a modern series using image-guided technologies either in the regular operating room or in the intraoperative magnetic resonance imaging unit. ⋯ Gross total resection of brain metastases, including those involving critical function areas, can be safely achieved with a low morbidity rate using contemporary image-guided systems. RPA Class I and II patients with controlled primary disease benefit from aggressive treatment by surgery and radiation.
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To the ability of the fentanyl patch to control pain in a postoperative canine model, we provided two male beagles with 25-mg/h patches and two with 50-mg/h patches 24 h prior to surgery. Each animal underwent a major abdominal surgical procedure to place three separate catheters with associated vascular access ports. Serum plasma levels of fentanyl were analyzed at multiple time points throughout the study period. ⋯ Fentanyl concentrations remained at the reported human analgesic levels in all animals between 2 to 4 h after the patches were removed. Regardless of the dose, decreases in heart rate, respiration rate, and temperature were observed in all four animals 12 h after placing the patches. Issues regarding the regulatory requirements to prevent drug abuse, the side effects and potency of fentanyl, and the prolonged duration of action as a transdermal system should be addressed by the veterinarian when considering usage of this analgesic method.
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Curr Opin Anaesthesiol · Jun 2003
Anaesthetic considerations in patients with chronic pulmonary disease.
Chronic pulmonary diseases are getting more important in daily anaesthetic practice, because prevalence is increasing and improved anaesthetic techniques have led to the abandonment of previous contraindications to anaesthesia. It is therefore essential for the anaesthetist to be up to date with current clinical concepts and their impact on the conduction of anaesthesia as well as new insights into how to anaesthetise these patients safely. ⋯ Assessing the functional status of patients admitted for surgery remains a difficult task, and in patients identified as being at risk by clinical examination additional spirometry and blood gas measurements may be helpful. If there are flow limitations and signs of respiratory failure, the anaesthetist should be highly alarmed and monitor the patient closely and invasively, yet there is no reason to deny any patient a substantially beneficial operation.