Articles: disease.
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The coronavirus disease (COVID-19) outbreak is putting the European National Health Systems under pressure. Interestingly, Emergency Department (ED) referrals for reasons other than Covid-19 seem to have declined steeply. In the present paper, we aimed to verify how the Covid-19 outbreak changed ED referral pattern. ⋯ The Covid-19 pandemic completely changed the pattern of ED referral in Italy, with a marked reduction of the accesses to the hospitals. This could be related to a limited exposure to traumas and to a common fear of being infected during EDs in-stay. This may limit the misuse of EDs for non- urgent conditions, but may also delay proper referrals for urgent conditions.
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Tijdschr Econ Soc Geogr · Jun 2020
Island Geographies of Separation and Cohesion: The Coronavirus (COVID-19) Pandemic and the Geopolitics of Kalaallit Nunaat (Greenland).
Kalaallit Nunaat (Greenland) is an Arctic highly autonomous subnational island jurisdiction (SNIJ) of Denmark, its former coloniser. The coronavirus (COVID-19) pandemic of 2020 has influenced both Kalaallit Nunaat's relations with the outside world and relations between people and places within the territory. ⋯ This strategy, however, is challenged both by the SNIJ's economic reliance on Denmark and by the Danish government's own strategy of mitigating the disease. This paper explores the ways in which the coronavirus pandemic has altered how the people of Kalaallit Nunaat interact with the people of Denmark and with one another, ultimately shedding light on the relationship between islands, disease, and geopolitics more generally.
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Non-alcoholic fatty liver disease (NAFLD), especially non-alcoholic steatohepatitis, which is considered as the hepatic manifestation of metabolic syndrome, has a great prevalence all over the world. New drugs are urgently needed for the treatment of NAFLD. This review will be to assess the efficacy and safety of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on liver-related outcomes (liver histology and liver enzymes) in patients with NAFLD. ⋯ INPLASY202050008.
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Observational Study
Clinicopathologic characteristics of resectable colorectal cancer with mismatch repair protein defects in Chinese population: Retrospective case series and literature review.
Colorectal cancer (CRC) represents a major malignancy globally, with microsatellite instability as its second top molecular mechanism of carcinogenesis. Immunohistochemical (IHC), whose sensitivity and specificity exceed 90%, is used routinely to detect 4 MMR proteins (MLH1, PMS2, MSH2, and MSH6) for screening mismatch repair system defects. We aimed to assess associations of clinicopathologic characteristics with MMR status in resectable CRC patients. ⋯ Five-year overall survival (OS) rates were 84.2% and 79.2% in left-side and right-side cases, respectively; 5-year disease-free survival (DFS) rates were 74.0% and 69.8%, respectively. Survival had no differences between left- and right-side patients in terms of OS (P = .318) and DFS (P = .481). These data demonstrate that 4 major dMMR proteins are expressed differently in left- and right-side CRCs, and survival is comparable in right- and left-side resectable CRC cases with dMMR.