Articles: disease.
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Travel Med Infect Dis · May 2018
Diarrhea and related factors among passengers on world cruises departing from Japan.
Despite growth in the number of cruises worldwide, evidence about diarrhea experienced by cruise ship passengers remains sparse. We investigated rates of diarrhea and related factors among passengers on world cruises departing from Japan. ⋯ Older passengers and passengers with fewer roommates may be more likely to seek medical treatment for diarrhea during travel on a world cruise, and should take preventive measures.
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To establish a possible relation of dependency between pulmonary hypertension (PHT) and several factors, with the evaluation of their predictive potential, in Graves' disease. ⋯ The non-linear model best explains the relation of determination between pulmonary pressure and those factors having a better predictive potential (from 51% to 90%), compared with the linear model, the only exception being the age factor and the systolic blood pressure, where both models seems to be appropriate.
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There is a significant interest in the standardized classification of human genetic variants. We used whole-genome sequence data from 10,495 unrelated individuals to contrast population frequency of pathogenic variants to the expected population prevalence of the disease. Analyses included the ACMG-recommended 59 gene-condition sets for incidental findings and 463 genes associated with 265 OrphaNet conditions. ⋯ The burden of rare variants was a main contributing factor of the observed inflation, indicating collective misclassified rare variants. We also analyzed the dynamics of re-classification of variant pathogenicity in ClinVar over time, which indicates progressive improvement in variant classification. The study shows that databases include a significant proportion of wrongly ascertained variants; however, it underscores the critical role of ClinVar to contrast claims and foster validation across submitters.