Articles: disease.
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To review the criteria for diagnosis of HIV infection in adults in order to improve upon the Zimbabwe Adult AIDS case definition. ⋯ This study has shown that the criterion used in the diagnosis of HIV infection in Zimbabwe is highly specific but relatively insensitive at identifying seropositive patients. This shows the ability of clinicians to identify HIV positive patients irrespective of the stage of the disease (i.e. HIV related symptoms, AIDS related complex or full blown AIDS). There is also a need for constant monitoring of the clinical manifestations of AIDS patients to keep abreast with newer disease manifestations.
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To examine the relation of circulating cytokines and cytokine antagonists to the progression of human immunodeficiency virus type 1 (HIV-1) disease. ⋯ High circulating levels of the proinflammatory cytokines interleukin-1beta and TNF-alpha, combined with an excess of their natural inhibitors interleukin-1Ra and TNF-sRp55, were seen in clinically asymptomatic HIV-1-positive African women but not in African women with AIDS or in HIV-negative controls. Circulating cytokine antagonists may play a clinical role in modulating cytokine-associated symptoms in the early phases of HIV infection.
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J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. · Apr 1996
Cesarean deliveries and maternal-infant HIV transmission: results from a prospective study in South Africa.
Data from a prospective study undertaken at an urban hospital in Durban, South Africa, were used to investigate associations between maternal-infant HIV transmission, mode of delivery, and specific circumstances of cesarean deliveries. A total of 141 children of HIV-infected women were followed until the children were 15 months of age to determine their HIV status. supplementary data were collected from obstetric records, masked to the HIV status of the children. ⋯ Singleton cesarean deliveries without concurrent obstetric complications had lower rates of transmission than did vaginal deliveries (OR, 0.20; 95% CI, 0.04-0.94). These results suggest that certain intrapartum events may modify the risk of HIV transmission and highlight the importance of collecting more detailed intrapartum information in order to clarify the route by which mode of delivery may be associated with maternal-infant HIV transmission.