Articles: disease.
-
Myelin oligodendrocyte glycoprotein antibody (MOGA) associated diseases are inflammatory immune-mediated demyelinating disorders with relapse potential involving the central nervous system. Multiple unusual clinical manifestations of those disorders were reported, making treatment decisions difficult. ⋯ MOGA-associated disorders have a variety of clinical features, so a high index of suspicion is required for their diagnosis. Papilledema and an elevated ICP are 2 of the chameleons of MOGA-associated disorders. MOGA test may be useful in patients with elevated ICP and inflammatory cerebrospinal fluid profiles. An investigation of the possible association between those disorders and high ICP is warranted.
-
Patients with heart disease often feel helpless and anxious because of illnesses in their vital organs. Unfamiliar environment of the intensive care unit is another factor that increases patient anxiety. This study developed audiovisual media-based information on nursing after open-heart surgery and evaluated its effect on patients' post-surgery, with the aim of reducing patients' environmental stress, anxiety, and uncertainty. ⋯ There was a significant difference in anxiety between the mean pretest-posttest scores, with 0.39 ± 0.35 points in the experimental group, and -0.05 ± 0.58 points in the control group (t = 5.165, P < .001). On the other hand, there was a significant difference in uncertainty between the mean pretest-posttest scores, with 0.39 ± 0.4 points in the experimental group, and 0.24 ± 0.48 points in the control group (t = 4.541, P < .001). This finding indicates that providing audiovisual information regarding nursing before open-heart surgery is effective in reducing environmental stress, anxiety, and uncertainty in patients.
-
Malignant primary brain tumors cause more than 15 000 deaths per year in the United States. The annual incidence of primary malignant brain tumors is approximately 7 per 100 000 individuals and increases with age. Five-year survival is approximately 36%. ⋯ The incidence of primary malignant brain tumors is approximately 7 per 100 000 individuals, and approximately 49% of primary malignant brain tumors are glioblastomas. Most patients die from progressive disease. First-line therapy for glioblastoma is surgery followed by radiation and the alkylating chemotherapeutic agent temozolomide.
-
Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease.
Numerous studies have established the association of the common APOE ε2 and APOE ε4 alleles with Alzheimer disease (AD) risk across ancestries. Studies of the interaction of these alleles with other amino acid changes on APOE in non-European ancestries are lacking and may improve ancestry-specific risk prediction. ⋯ In this exploratory analysis, the APOE ε3[R145C] missense variant was associated with an increased risk of AD among individuals of African ancestry with the ε3/ε4 genotype. With additional external validation, these findings may inform AD genetic risk assessment in individuals of African ancestry.