Articles: disease.
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Schistosomiasis is a widespread disease that can cause serious health issues if not diagnosed and treated promptly. Fortunately, there is an effective and safe treatment available: praziquantel (PZQ). In countries with a high influx of migrants from schistosomiasis-endemic regions, it is crucial to ensure the availability of PZQ. This discussion will address the barriers and the need for PZQ in Italy.
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Ustekinumab is an effective drug in the treatment of inflammatory bowel disease (IBD), but inadequate response or loss of response is reported in several patients. Dose escalation by intravenous reinduction or interval shortening may be a suitable option to recapture response. We undertook a systematic review and meta-analysis to assess the efficacy of dose escalation in IBD patients receiving ustekinumab. ⋯ This systematic review and meta-analysis showcased promising results, in terms of clinical response and remission, in IBD patients receiving dose escalation of ustekinumab.
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World Neglected Tropical Diseases (NTD) Day on January 30th, with the theme 'Unite. Act. Eliminate.', emphasizes the global fight against NTDs, underlining efforts to address the inequalities that perpetuate NTDs. This article explores the milestones and calls for sustained collaboration to achieve a healthier, more equitable future for vulnerable populations.
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Chronic obstructive pulmonary disease affects more than 65 million people worldwide. Lung transplantation is the only definitive treatment. However, donor availability is limited in meeting the demand. ⋯ The lung's ability to regenerate extensively after injury suggests that this capability could be promoted in diseases in which loss of lung tissue occurs. Lung bioengineering offers the potential to drastically extend life expectancy in patients with end-stage lung disease. If lung reengineering were successful, it would revolutionize the world of transplantation.