Articles: back-pain.
-
Randomized Controlled Trial
Effect of Minocycline on Lumbar Radicular Neuropathic Pain: A Randomized, Placebo-controlled, Double-blind Clinical Trial with Amitriptyline as a Comparator.
Less than 50% of patients experience sufficient pain relief with current drug therapy for neuropathic pain. Minocycline shows promising results in rodent models of neuropathic pain but was not studied in humans with regard to the treatment of neuropathic pain. ⋯ Although both groups differed from placebo, their effect size was small and therefore not likely to be clinically meaningful.
-
Review Meta Analysis
Epidural injections in prevention of surgery for spinal pain: systematic review and meta-analysis of randomized controlled trials.
Low back pain is debilitating and costly, especially for patients not responding to conservative therapy and requiring surgery. ⋯ Epidural steroid injections may provide a small surgery-sparing effect in the short term compared with control injections and reduce the need for surgery in some patients who would otherwise proceed to surgery.
-
Human brain mapping · Feb 2015
Observational StudySmoking increases risk of pain chronification through shared corticostriatal circuitry.
Smoking is associated with increased incidence of chronic pain. However, the evidence is cross-sectional in nature, and underlying mechanisms remain unclear. In a longitudinal observational study, we examined the relationship between smoking, transition to chronic pain, and brain physiology. ⋯ Mediation analysis indicated the prediction of BP persistence by smoking was largely due to synchrony of fMRI activity between two brain areas (nucleus accumbens and medial prefrontal cortex, NAc-mPFC). In SBP or CBP who ceased smoking strength of NAc-mPFC decreased from precessation to postcessation of smoking. We conclude that smoking increases risk of transitioning to CBP, an effect mediated by corticostriatal circuitry involved in addictive behavior and motivated learning.
-
Observational Study
Patient-reported outcomes associated with use of physical therapist services by older adults with a new visit for back pain.
Among older adults, it is not clear how different types or amounts of physical therapy may be associated with improvements in back pain and function. ⋯ Higher amounts of active physical therapy were most consistently related to the greatest improvements in pain intensity; however, as with all observational studies, the results must be interpreted with caution.
-
Observational Study
Influence of pain sensitivity on surgical outcomes after lumbar spine surgery in patients with lumbar spinal stenosis.
Prospective observational study. ⋯ 2.