Articles: child.
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J Dev Orig Health Dis · Aug 2015
Multicenter StudyVitamin D exposure during pregnancy, but not early childhood, is associated with risk of childhood wheezing.
The association between vitamin D and wheezing in early childhood is unclear. The primary objective of this study was to evaluate the association between vitamin D exposure, during both pregnancy and childhood, and early childhood wheezing. Secondary objectives were to evaluate the associations between vitamin D exposures and asthma and wheezing severity. ⋯ No significant associations were observed with diagnosed asthma or wheezing severity. Vitamin D supplementation during pregnancy was associated with reduced odds of wheezing, but child vitamin D supplementation and childhood 25(OH)D were not associated with reduced wheezing. The timing of exposure may be important in understanding the association between vitamin D and childhood wheezing.
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Pediatr Crit Care Me · Jul 2015
Multicenter StudyFactor VIII May Predict Catheter-Related Thrombosis in Critically Ill Children: A Preliminary Study.
If we can identify critically ill children at high risk for central venous catheter-related thrombosis, then we could target them for pharmacologic thromboprophylaxis. We determined whether factor VIII activity or G value was associated with catheter-related thrombosis in critically ill children. ⋯ Factor VIII activity may be used to stratify critically ill children based on their risk for catheter-related thrombosis.
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Multicenter Study Observational Study
Adequate enteral protein intake is inversely associated with 60-d mortality in critically ill children: a multicenter, prospective, cohort study.
The impact of protein intake on outcomes in pediatric critical illness is unclear. ⋯ Delivery of >60% of the prescribed protein intake is associated with lower odds of mortality in mechanically ventilated children. Optimal prescription and modifiable practices at the bedside might enhance enteral protein delivery in the PICU with a potential for improved outcomes. This trial was registered at clinicaltrials.gov as NCT02354521.
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Multicenter Study Comparative Study
Parasol Rib Deformity in Hypotonic Neuromuscular Scoliosis: A New Radiographical Definition and a Comparison of Short-term Treatment Outcomes With VEPTR and Growing Rods.
Retrospective review of 2 multicenter national databases, Growing Spine Study Group and Chest Wall and Spine Deformity. ⋯ 4.
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Am. J. Respir. Crit. Care Med. · Jun 2015
Multicenter Study Observational StudyIndications and Effects of Plasma Transfusions in Critically Ill Children.
Plasma transfusions are frequently prescribed for critically ill children, although their indications lack a strong evidence base. Plasma transfusions are largely driven by physician conceptions of need, and these are poorly documented in pediatric intensive care patients. ⋯ One-third of transfused patients were not bleeding and had no planned procedure. In addition, in most patients, coagulation tests are not sensitive to increases in coagulation factors resulting from plasma transfusion. Studies assessing appropriate plasma transfusion strategies are urgently needed.