Articles: postoperative-pain.
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Randomized Controlled Trial Clinical Trial
Low-dose intrathecal diamorphine analgesia following major orthopaedic surgery.
In a randomized double-blind study we examined the effect of adding diamorphine 0.25 mg and 0.5 mg to intrathecal bupivacaine anaesthesia for major orthopaedic surgery. Duration of postoperative analgesia was considerably greater in patients given either doses of intrathecal diamorphine than in a control group of patients given bupivacaine alone (P less than 0.001). However, there was no significant difference between the two diamorphine doses (0.25 mg and 0.5 mg), each providing prolonged analgesia (10.8 and 9.9 h, respectively). Although there was no evidence of late respiratory depression, the frequency of adverse effects, in particular urinary retention, nausea and vomiting, was high in both groups receiving intrathecal diamorphine.
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Randomized Controlled Trial Clinical Trial
[Effectiveness of infiltration anesthesia of postoperative abdominal wound using bupivacaine solution for alleviation of postoperative pain].
In a group of 40 patients after abdominal operations a high effectiveness was noted of infiltrations anaesthesia of the postoperative wound with 0.5% bupivacaine solution for alleviation of pain and reduction of requirements for narcotics in early postoperative period (randomized study).
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Anesthesia and analgesia · Feb 1989
Randomized Controlled Trial Clinical TrialProphylactic transdermal scopolamine patches reduce nausea in postoperative patients receiving epidural morphine.
To evaluate the efficacy of prophylactic transdermal scopolamine in reducing nausea associated with postoperative epidural analgesia, we studied 32 healthy adult women undergoing major gynecologic surgery. The patients were randomized in a double blind fashion to receive either a cutaneous scopolamine patch or a visually identical cutaneous placebo patch. Postoperative analgesia was provided solely with epidural morphine. ⋯ The number of patients reporting "zero nausea" was significantly greater with scopolamine patches than with placebo patches (13 vs 1, P less than 0.01). The mean number of times antiemetic drugs were administered per patient was lower with scopolamine than with placebo patches (0.2 +/- 0.4 vs 2.8 +/- 2.6, P less than 0.05). It is concluded that prophylactic transdermal scopolamine patches reduce nausea in postoperative patients receiving epidural morphine.
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison of continuous paravertebral and extradural infusions of bupivacaine for pain relief after thoracotomy.
Pain was controlled in 20 post-thoracotomy patients using a continuous infusion of 0.25% bupivacaine through an extradural or para-vertebral catheter. Both techniques provided good analgesia. Hypotension and urine retention occurred significantly less frequently in the paravertebral than in the extradural group.