Articles: postoperative-pain.
-
Randomized Controlled Trial Comparative Study Clinical Trial Controlled Clinical Trial
Comparative study of ketorolac and paracetamol/codeine in alleviating pain following gynaecological surgery.
In a randomized, double-blind, multiple-dose, parallel study of 107 patients, the safety and analgesic efficacy of single and multiple doses of orally administered ketorolac tromethamine (10-40 mg/day) were compared with orally administered paracetamol (1000-4000 mg/day)/codeine (60-240 mg/day) for treating moderate to severe pain after gynaecological surgery. Both drugs effectively reduced pain intensity. After the first dose of medication, over 90% of the patients in each treatment group reported pain reduction of at least 50%. ⋯ No statistically significant differences in analgesic efficacy were observed in the two treatment groups. Ketorolac tromethamine-treated patients reported a total of 62 adverse events (17 considered drug-related) and the paracetamol/codeine-treated patients reported 65 (20 considered drug-related); the adverse event profiles of the two treatment regimens were similar. Thus, both the single and the multiple doses of ketorolac tromethamine (10 mg) alleviated moderate to severe pain after gynaecological surgery as safely and efficaciously as paracetamol (1000 mg)/codeine (60 mg).
-
Comparative Study
Patient-controlled analgesia in orthopedic procedures.
-
Anesthesia and analgesia · Nov 1988
Clinical Trial Controlled Clinical TrialA dose-response study of intrathecal morphine: efficacy, duration, optimal dose, and side effects.
We performed a double-blind study of the dose-response relationship of intrathecal morphine (0, 0.3, 1, and 2.5 mg) for postoperative pain relief in 33 subjects who underwent total knee or hip replacement surgery. Assessments commenced 1 hour after the opioid injection, which was given at the end of surgery, and continued for 24 hours. Pain measurements, supplementary analgesia requirements, and adverse effects were recorded. ⋯ Pruritus was unique to intrathecal morphine administration, but nausea, vomiting, and urinary retention were common in all the groups. We conclude that no ideal dose of intrathecal morphine exists because, even with small quantities, minor adverse effects are evident. Doses between 0.3 and 1 mg, however, should provide good analgesia free from the major complication, respiratory depression.
-
Acta Anaesthesiol Scand · Nov 1988
Randomized Controlled Trial Clinical TrialEpidural clonidine for treatment of postoperative pain after thoracotomy. A double-blind placebo-controlled study.
Clonidine has been reported to produce analgesia in humans in different painful conditions. The aim of the present study was to investigate if epidural clonidine produced a clinically important analgesia to severe postoperative pain. Using a controlled, randomized double-blind design, one group of patients received a single dose of epidural clonidine 3 micrograms/kg (n = 10) and a control group epidural 0.9% saline (n = 10), when reporting postoperative pain after thoracotomy performed under standardized anaesthesia. ⋯ The side-effects of epidural clonidine were tolerable, and no treatment for arterial hypotension was required. No early or delayed respiratory depression occurred. In conclusion, clonidine 3 micrograms/kg epidurally seems to lack clinically important analgesic effects on severe postoperative pain, at least following thoracotomy.