Articles: postoperative-pain.
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Br J Oral Maxillofac Surg · Dec 1985
An investigation into post-operative pain after third molar surgery under local analgesia.
The pain experienced after third molar surgery was investigated over a 7 day post-operative period in 80 patients. The results from the study suggest that post-operative pain is of short duration and reaches its maximum intensity in the early post-operative period. ⋯ The sex of the patient and whether there is a previous history of pericoronitis are important determinants of post-operative pain. However, the magnitude of post-operative pain does not appear to be dependent upon the operator or related to the extent of surgical trauma as assessed by operating time and radiographic score.
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Eight patients undergoing abdominal surgery received epidural analgesia with 0.5% plain bupivacaine at a fixed dose rate (8 ml/h) for postoperative pain relief. Mean sensory level of analgesia (pin prick) was assessed hourly and regressed from a mean preoperative level of T3.7 (+/- 0.3 SEM) to T10 (+/- 0.7) at an average of 8.9 +/- 1.4 h post skin incision (range 4-16 h). ⋯ Simultaneously, pain score decreased to 0.3 +/- 0.3. This synergistic effect of systemic morphine on the extent of neural blockade with epidural bupivacaine may have an important role in improving postoperative pain relief.
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Comparative Study Clinical Trial Controlled Clinical Trial
Double-blind placebo-controlled comparison of dezocine and morphine for post-operative pain relief.
Dezocine, a new mixed agonist-antagonist-type opioid analgesic, was compared in a double-blind trial with placebo and 10 mg of morphine in 190 patients with acute postoperative pain. The medications were given intramuscularly. Dezocine was administered at three dose levels (5, 10, and 15 mg). ⋯ Side effects were few with no significant differences between the treatment groups. Seventy-nine per cent of the patients in the dezocine 15 mg group, and 73, 68, 58 and 50 per cent respectively, of the patients in the dezocine 10 mg, dezocine 5 mg, morphine 10 mg and placebo group had a satisfactory clinical response. Significantly (p less than 0.05) more patients in the groups receiving dezocine 10 and 15 mg than in the placebo group had a satisfactory clinical response; the difference was not significant for the dezocine 5 mg and morphine 10 mg groups.(ABSTRACT TRUNCATED AT 250 WORDS)
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Anesthesia and analgesia · Nov 1985
Randomized Controlled Trial Comparative Study Clinical TrialA double-blind comparison of multiple intramuscular doses of ciramadol, morphine, and placebo for the treatment of postoperative pain.
Ciramadol, an agonist-antagonist analgesic (in intramuscular doses of 30 and 60 mg) was compared with 10 mg of morphine and placebo in a double-blind, parallel study in 160 patients with postoperative pain. The patients were assigned randomly to one of the four treatment groups and could receive a dose of the medication every 3 hr as needed for 48 hr; a maximum of six doses was allowed in a 24-hr period. Formal efficacy assessments using standard pain intensity and pain relief scales were restricted to the initial dose period. ⋯ Sedation was slightly higher with the active therapies than with placebo. Changes in vital signs were minimal. It is concluded that 60 mg of ciramadol compares favorably with 10 mg of morphine as a postoperative analgesic.
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Int J Clin Pharmacol Ther Toxicol · Nov 1985
Randomized Controlled Trial Comparative Study Clinical TrialPostextraction pain relief in children: a clinical trial of liquid analgesics.
Our objective was to evaluate the relative efficacies of four liquid analgesics in children, five to twelve years of age, following dental extractions. The analgesics, acetaminophen elixir (240 or 360 mg), acetaminophen with codeine elixir (240 mg and 24 mg, respectively), aluminum ibuprofen suspension (200 mg), and placebo liquid were administered at home, as a single dose, in a randomized double-blind study design. Of the 154 patients enrolled, 45 were evaluated, 39 patients never required medication, 12 were lost to follow-up, and 8 were excluded for other reasons. ⋯ The global rating of drug efficacy was statistically superior for aluminum ibuprofen. The majority of patients in all four groups were pain-free after four hours. No adverse reactions were reported during the study.