Articles: postoperative-pain.
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Eur. J. Clin. Pharmacol. · Jan 1981
Randomized Controlled Trial Clinical TrialPharmacokinetics of parenteral paracetamol and its analgesic effects in post-operative dental pain.
A double-blind, randomised, crossover trial was undertaken to compare the analgesic effects of a single dose of paracetamol (1000 mg i.v.) with placebo in the immediate post-operative period following removal of impacted lower third molars. There was no significant difference in the pain relief between paracetamol and placebo in the first hour following injection. ⋯ Plasma concentrations of paracetamol were measured and pharmacokinetic variables were determined. Over the four hour period of investigation there was no clear relationship between analgesia and paracetamol concentration in either central or peripheral compartments.
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Clinical therapeutics · Jan 1981
Comparative Study Clinical TrialKetamine fro postoperative analgesia after upper abdominal surgery.
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Clin. Pharmacol. Ther. · Dec 1980
Age and morphine analgesia in cancer patients with postoperative pain.
Our objective was to identify age-related differences in analgesia after 8 and 16 mg morphine intramuscularly. Retrospective analyses of controlled relative analgesic potency assays in 947 postoperative cancer patients revealed differences among age groups (18 to 29, 30 to 49, 50 to 69, and 70 to 89 yr) in total pain relief and duration of relief with little differences in peak relief. Weight and initial pain intensity were in the same range among age and dose groups. ⋯ The difference in total relief between the extremes of adult age was approximately twice that with twice the dose. While in 50% of the oldest group relief was no longer obtained at 5 hr, in 50% of the youngest group relief was no longer obtained at 3 hr. These observations suggest that age is a factor in morphine analgesia.
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Acta Anaesthesiol Scand · Dec 1980
Comparative Study Clinical TrialDouble-blind, multiple-dose comparison of buprenorphine and morphine in postoperative pain.
The analgesic profile and side-effects of buprenorphine 0.3 mg and morphine 10 mg intramuscularly were compared postoperatively in a double-blind, non-crossover, multiple-dose study. When the patient complained of moderate to severe postoperative pain after halothane-relaxant anesthesia for upper abdominal surgery, the first test dose of either drug was given. Subsequent similar doses of buprenorphine 0.3 mg or morphine 10 mg were given when required (maximum ten doses). ⋯ Other effects of the two drugs on vital signs were similar. The incidence of other side-effects was fairly similar after both analgesics. The patients' subjective appraisal favoured buprenorphine.
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Morphine 2 mg was injected directly into the intrathecal space in 33 patients. In the nonoperative group (group I) morphine was given with 2 ml saline solution; in the operative group (group II, 21 patients) morphine was given with 2 ml 10% glucose solution immediately before induction of anaesthesia. The onset of pain relief occurred after 12 to 35 min and the duration of analgesia was 14 and 18 35 min and the duration of analgesia was 14 and 48 hours. ⋯ In group I bladder insufficiency occurred in 2 cases. The disturbed bladder function recovered spontaneously in a few hours after morphine application. Respiratory depression was treated successfully with naloxone.