Articles: human.
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Evid Based Compl Alt · Jan 2013
Fermented wheat germ extract induced cell death and enhanced cytotoxicity of Cisplatin and 5-Fluorouracil on human hepatocellular carcinoma cells.
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death worldwide. Due to the difficulties of early diagnosis, curative treatments are not available for most patients. Palliative treatments such as chemotherapy are often associated with low response rate, strong adverse effects and limited clinical benefits for patients. ⋯ FWGE also induced Poly (Adenosine diphosphate ribose) polymerase (PARP) associated cell death in Hep3B cells. Moreover, the FWGE treatment further enhanced the cytotoxicity of cisplatin in all tested HCC cells, and cytotoxicity of 5-Fu in a synergistic manner in HepJ5 cells. Collectively, the results identified the anti-tumor efficacy of FWGE in HCC cells and suggested that FWGE can be used as a supplement to effectively improve the tumor suppression efficiency of cisplatin and 5-Fu in HCC cells.
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The objective of this project was to reduce patient falls and falls with injury on three oncology divisions at a large urban teaching hospital. By standardizing assessment, intervention, and post-fall investigation processes the goal was to decrease patient falls and falls with injury rate by 50% and 30%, respectively. ⋯ Case study, falls, hospital, human factors, organizational transformation, patients.
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The purpose of our study was to organize the literature regarding the efficacy of modern videolaryngoscopes in oral endotracheal intubation, then perform a quality assessment according to recommended external criteria and make recommendations for use. ⋯ In patients at higher risk of difficult laryngoscopy we recommend the use of the Airtraq, CTrach, GlideScope, Pentax AWS and V-MAC to achieve successful intubation. In difficult direct laryngoscopy (C&L >/= 3) we cautiously recommend the use of the Airtraq, Bonfils, Bullard, CTrach, GlideScope, and Pentax AWS, by an operator with reasonable prior experience, to achieve successful intubation when used in accordance with the ASA practice guidelines for management of the difficult airway. There is additional evidence to support the use of the Airtraq, Bonfils, CTrach, GlideScope, McGrath, and Pentax AWS following failed intubation via direct laryngoscopy to achieve successful intubation. Future investigation would benefit from precise qualification of the subjects under study, and an improvement in overall methodology to include randomization and blinding.
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BACKGROUND Little is known about adult-onset opsoclonus-myoclonus syndrome (OMS) outside of individual case reports. OBJECTIVE To describe adult-onset OMS. DESIGN Review of medical records (January 1, 1990, through December 31, 2011), prospective telephone surveillance, and literature review (January 1, 1967, through December 31, 2011). ⋯ CONCLUSIONS Adult-onset OMS is rare. Paraneoplastic and parainfectious causes (particularly human immunodeficiency virus) should be considered. Complete remission achieved with immunotherapy is the most common outcome.
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Expert Rev Endocrinol Metab · Nov 2012
Research and development in the molecular genetics of pituitary adenomas and related tumors.
Interview by Rona Williamson Constantine A Stratakis received his MD and Doctor of Medical Sciences degrees from the University of Athens (Greece) in 1989 and 1994, respectively; he did predoctoral work at the Unit of Endocrinology, Department of Experimental Pharmacology of the same University and at Hospital Cochin (Paris, France), before joining the Developmental Endocrinology Branch of the then National Institute of Child Health & Human Development (NICHD) at the NIH (MD, USA). He continued his postgraduate medical education at Georgetown University Medical School (DC, USA), where he finished a residency in Pediatrics and two fellowships, in Pediatric Endocrinology, followed by Medical Genetics and Clinical Dysmorphology (in a joint program with the then newly founded National Center for Genomic Research, now NHGRI). Dr Stratakis is Board-certified in Pediatrics, Pediatric Endocrinology and Medical Genetics; after a brief stint as faculty at Georgetown University Department of Pediatrics and the Fairfax Children's Hospital, he joined the Developmental Endocrinology Branch, NICHD, NIH as a Unit Chief in 1996; he continued there as a Senior Investigator and Chief of the Section on Genetics & Endocrinology. ⋯ Dr Stratakis has been the recipient of the 1999 Pharmacia-Endocrine Society Award for Excellence in Published Clinical Research, three NIH Merit Awards and other honors, and has been named Visiting Professor in academic centers around the world. He was awarded the 2009 Ernst Oppenheimer Award of the Endocrine Society. Dr Stratakis has been the Scientific Director of the Eunice Kennedy Shriver National Institute of Child Health & Human Development since 2011.