Articles: general-anesthesia.
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Clinical Trial Controlled Clinical Trial
Neuromuscular and cardiovascular effects of mivacurium chloride (BW B1090U) during nitrous oxide-fentanyl-thiopentone and nitrous oxide-halothane anaesthesia.
Seventy-two adult surgical patients were studied to compare neuromuscular and cardiovascular effects of mivacurium chloride during nitrous oxide-fentanyl-thiopentone (BAL group) or nitrous oxide-halothane (HAL group) anaesthesia. Eighteen patients in the BAL group received an initial bolus of mivacurium, either the ED25 (n = 9) or the ED50 (n = 9) (0.03 and 0.05 mg kg-1). These doses were based on the assumption that the slope of the dose-response curve during nitrous oxide-opioid anaesthesia would be approximately the same as the slope of the neuromuscular response from the first human studies with mivacurium. ⋯ With the 0.15-mg kg-1 dose, time to 95% recovery was prolonged significantly in the HAL group (30.0 (SEM 1.4) min) compared with the BAL group (24.1 (1.5) min). Recovery index from 25% to 75% recovery was also prolonged significantly in the HAL group (7.0 (0.4) min) compared with the BAL group (5.4 (0.4) min). There were no significant haemodynamic changes in groups given mivacurium doses up to and including 2 x ED95 by bolus i.v. administration.
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In a study of 247 patients who had general anaesthesia for dental procedures, the incidence of individual anxieties was noted using a questionnaire completed by the patient. The most common anxieties related to the period before transfer to the operating theatre, intra-operative awareness and postoperative pain. ⋯ The follow-up questionnaire was completed by 207 patients in order to indicate which anxieties they would expect to have if they needed anaesthesia in the future. All anxieties were less frequent than found before operation.
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Tidsskr. Nor. Laegeforen. · Jan 1990
[Causes and risk factors of intraoperative anesthesia complications. A prospective study of 14,735 anesthesias].
Identification of risk factors is an essential part of our efforts to minimize problems during anesthesia. 14,735 patients were included in a prospective study in order to assess the magnitude of risk and identify risk factors. The rate of complications increased substantially after the age of 40, due mainly to a large number of patients with poor preoperative physical condition. High age in itself was not associated with increased risk of complications. ⋯ The complications were related to the conduct of anaesthesia in 70% of the total number of cases and to poor physical status and the surgery in 30%. However, poor physical condition and the surgery were responsible for 50% of the very serious complications and for all the four deaths on the table. The results of the survey confirm that thorough preoperative preparation of the patient is extremely important in order to reduce intraoperative risk, especially in emergency surgery.
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Tidsskr. Nor. Laegeforen. · Jan 1990
[Registration of problems during anesthesia. Analysis of risk factors and quality control].
Society continues to increase its demands on the medical profession in regard to quality. We believe this situation should be met by a more systematic approach to risk evaluation and quality assessment of our work. We report an attempt to establish a routine system for recording complications during anesthesia. ⋯ Problems such as drop in blood pressure, intubation, laryngeal spasm and cardiac arrhythmias dominated. Such registration increases awareness for the safety of the patients, and enables us to assess the risk and evaluate the quality of our work. The system is now an integral part of the department's routine.
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Case Reports
Anaesthesia for a patient with central alveolar hypoventilation syndrome (Ondine's Curse).
The perioperative anaesthetic management of an adult patient with central alveolar hypoventilation syndrome (CAHS), Ondine's Curse, is described for anterior resection of a carcinoma of the bowel. This rare syndrome results in alveolar hypoventilation, hypercarbia, hypoxaemia with secondary polycythaemia, pulmonary artery hypertension, and cor pulmonale. ⋯ However, postoperative mechanical ventilation was required until recovery of the respiratory drive, which was ablated by anaesthetic drugs, epidural morphine and high inspired oxygen concentrations. The pathophysiology and treatment of this syndrome are reviewed.