Articles: general-anesthesia.
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Letter Comparative Study
One-year Outcomes of Spinal versus General Anesthesia: Comment.
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Letter Comparative Study
One-year Outcomes of Spinal versus General Anesthesia: Reply.
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J Clin Monit Comput · Oct 2024
Vasoconstriction with phenylephrine increases cardiac output in preload dependent patients.
General Anaesthesia (GA) is accompanied by a marked decrease in sympathetic outflow and thus loss of vasomotor control of cardiac preload. The use of vasoconstriction during GA has mainly focused on maintaining blood pressure. Phenylephrine (PE) is a pure α1-agonist without inotropic effects widely used to correct intraoperative hypotension. ⋯ During PE-infusion SVV was reduced to 6 ± 3%, CI increased to 2,6 ± 0,5 L/min*m2, and SVI increased to 49 ± 11mL/m2. All differences p < 0,001. In conclusion: Infusion of phenylephrine during preload dependency increased venous return abolishing preload dependency as evaluated by SVV and increased cardiac stroke volume and -output as measured by indicator-dilution technique. (ClinicalTrials.gov NCT05193097).
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Randomized Controlled Trial
Electroencephalographic features of elderly patients during anesthesia induction with remimazolam: a sub-study of a randomized controlled trial.
Although remimazolam is used as a general anesthetic in elderly patients due to its hemodynamic stability, the electroencephalogram characteristics of remimazolam are not well known. The purpose of this study was to identify the electroencephalographic features of remimazolam-induced unconsciousness in elderly patients and compare them with propofol. ⋯ Both regimens showed a greater decrease in feedback connectivity compared to a decrease in feedforward connectivity after loss of consciousness, leading to a disruption of asymmetry between the frontoparietal connectivity.
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Acta Anaesthesiol Scand · Oct 2024
Absorption pharmacokinetics and feasibility of intranasal dexmedetomidine in patients under general anaesthesia.
The use of intranasal dexmedetomidine is hampered by a limited understanding of its absorption pharmacokinetics. ⋯ Administration of intranasal dexmedetomidine in the supine position during general anaesthesia is feasible with good bioavailability. This administration method has slower absorption when compared to awake patients in upright position, with consequent concentrations attained after TMAX for several hours.