Articles: chronic-pain.
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The objective of this study was to explore the relationship between patterns of opioid use, pain severity, and pain-related mental health in chronic pain patients prescribed opioids. ⋯ The patterns in which patients use their opioid medications are associated with their psychological functioning. This is consistent with theory regarding the potential impact of reinforcing effects of opioid medication on functional outcomes. Interventions to encourage strategic or scheduled opioid use warrant investigation as methods to improve pain outcomes with opioids.
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Randomized Controlled Trial Comparative Study
[Long-term effects of interventional treatment on chronic pain of the musculoskeletal system. Retrospective outcome study of repeated in-patient treatment].
Interventional procedures are frequently used for treatment of musculoskeletal pain syndromes but current scientific evidence does not show successful outcome in chronic cases. In this study the effect of repeated interventional treatment on the long-term outcome of patients with chronic musculoskeletal pain was examined. ⋯ Repeated treatment cycles of interventional pain therapy did not lead to an improvement in the treated pain syndromes and in the long term the pain syndromes deteriorated further. It seems likely that the interventional approach promoted this adverse development but the data of this study are not sufficient to conclusively prove this thesis.
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This special issue of Experimental Neurology is devoted to the role of Microglia and Chronic Pain. Chronic pain affects 116 million people per year in the United States, which is more than heart disease, cancer, and diabetes combined. Nervous system trauma and disease are principal contributors to the establishment of chronic pain in people and in animal models. ⋯ Once considered to function solely as the phagocytotic cells of the CNS, more recent work has demonstrated that persistent activation of the microglial population may contribute to continued dysfunction including chronic pain. In the invited articles for this special issue on Microglia and Chronic Pain, we present evidence for the role of persistent microglial activation in chronic pain after peripheral and central nervous system injury, as well as in diabetic pain, post-herpetic neuralgia pain and related diseases. Collectively, the body of work indicates the importance of understanding the roles of microglial cells in chronic pain which will lead to targeted treatment to attenuate or alleviate chronic neuropathic pain syndromes.
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Ann Phys Rehabil Med · Apr 2012
Comparative StudyDisabling chronic low back pain with Modic type 1 MRI signal: acute reduction in pain with intradiscal corticotherapy.
The objective of the current study was to compare short- and long-term effect on chronic low back pain of intradiscal injection of methylprednisolone with or without presence of Modic type 1 MRI changes. ⋯ We suggest that patients with disabling chronic low back pain and Modic type 1 MRI changes have specific acute response to intradiscal injection of methylprednisolone. Clinical studies are however necessary to further investigate the effectiveness and safety of such injections.
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The objectives of this study were to evaluate 1) the prevalence of chronic and neuropathic pain features (NeP); 2) their comorbidities with psychiatric disorders and organic diseases; and 3) their impact on daily life and health care utilization. A random sample of 3011 participants (≥15 years), representative of Germany, was interviewed by telephone. Chronic pain duration was set at three months. ⋯ Individuals with obesity, diabetes, hypertension, cerebrovascular diseases, diseases of the nervous system, and diseases of the blood and blood-forming organs were at higher risk of having NeP but not non-NeP. These differences in prevalence and comorbidities between non-NeP and NeP features show how important it is to regard these different modalities of pain separately. Participants with NeP features suffer more and have greater impairment in their daily life than those with non-NeP.