Articles: pain-measurement.
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Meta Analysis
Epidural corticosteroid injections for sciatica: An Abridged Cochrane Systematic Review and Meta-Analysis.
Systematic with meta-analysis OBJECTIVES.: The aim of this study was to investigate the efficacy and safety of epidural corticosteroid injections compared with placebo injection in reducing leg pain and disability in patients with sciatica. ⋯ 1.
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Randomized Controlled Trial
INYBI: A New Tool for Self-Myofascial Release of the Suboccipital Muscles in Patients with Chronic Non-Specific Neck Pain: A Randomized Controlled Trial.
A randomized, single-blinded (the outcome assessor was unaware of participants' allocation group) controlled clinical trial. ⋯ 2.
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J Trauma Acute Care Surg · Nov 2020
Observational StudySpirometry not pain level predicts outcomes in geriatric patients with isolated rib fractures.
Geriatric patients with rib fractures are at risk for developing complications and are often admitted to a higher level of care (intensive care units [ICUs]) based on existing guidelines. Forced vital capacity (FVC) has been shown to correlate with outcomes in patients with rib fractures. Complete spirometry may quantify pulmonary capacity, predict outcome, and potentially assist with admission triage decisions. ⋯ Diagnostic test, level IV.
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When the nerve tissue is injured, endogenous agonist of melanocortin type 4 (MC4) receptor, α-MSH, exerts tonic pronociceptive action in the central nervous system, contributing to sustaining the neuropathic pain state and counteracting the analgesic effects of exogenous opioids. With the intent of enhancing opioid analgesia in neuropathy by blocking the MC4 activation, so-called parent compounds (opioid agonist, MC4 antagonist) were joined together using various linkers to create novel bifunctional hybrid compounds. Analgesic action of four hybrids was tested after intrathecal (i.t.) administration in mouse models of acute and neuropathic pain (chronic constriction injury model, CCI). ⋯ Opioid receptor antagonists and MC4 receptor agonists diminished the analgesic action of these two hybrids studied, though the extent of this effect differed between the hybrids; this suggests that linker is of key importance here. Further results indicate a significant advantage of hybrid compounds over the physical mixture of individual pharmacophores in their analgesic effect. All this evidence justifies the idea of synthesizing a bifunctional opioid agonist-linker-MC4 antagonist compound, as such structure may bring important benefits in neuropathic pain treatment.