Articles: treatment.
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Multicenter Study Pragmatic Clinical Trial
Traditional Chinese medicine FYTF-919 (Zhongfeng Xingnao oral prescription) for the treatment of acute intracerebral haemorrhage: a multicentre, randomised, placebo-controlled, double-blind, clinical trial.
There are few proven treatments for acute spontaneous intracerebral haemorrhage, and they all target reducing expansion of the haematoma. The traditional Chinese medicine FYTF-919 (Zhongfeng Xingnao) in an oral solution is comprised of several Chinese herbs that are widely used to treat patients with intracerebral haemorrhage in China on the understanding that they enhance resorption of the haematoma and reduce neuroinflammation. We aimed to provide a reliable assessment of the safety and efficacy of FYTF-919 in patients with moderate to severe acute intracerebral haemorrhage. ⋯ Key-Area Research and Development Program of Guangdong Province.
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With the advent of the first disease-modifying, anti-amyloid β-directed passive immunotherapy for Alzheimer's disease, questions arise who, when, and how to treat. This paper describes shortly the pathogenic basis of and preclinical data, which have, more than two decades ago, initiated the development of this vaccination therapy. We discuss clinical trial results of aducanumab, lecanemab, and donanemab. ⋯ Furthermore, estimations of numbers of patient who will qualify for treatment regarding inclusion and exclusion criteria and estimations on readiness of health-care systems for identifying the right patients and for providing the treatment are reported. In our view, we are experiencing a fundamental shift from syndrome-based Alzheimer's dementia care to early, biomarker-guided treatment of Alzheimer's disease. This shift requires substantial adjustments of infrastructure and resources, but also holds promise of eventually achieving substantial slowing of disease progression and delaying dementia.
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Improving the dietary behaviors of personnel can result in positive impact beyond the individual, creating benefits for their organization and wider society. Military personnel endure extended periods of physical and cognitive activity. Healthful dietary behaviors by military personnel support preparedness; yet poor diet behaviors remain common and persistent, and adversely impact health and physical and cognitive performance. Urgent and effective action is needed to improve diet behaviors, but this action has not been prioritized. This study aimed to estimate the value that could be realized from improved diet behaviors to support prioritization of investment in this area for policy and program change. ⋯ These estimates were constructed using the best available data and transparency within the calculations, but they remain estimates. The collection of additional data would enable the calculation of further outcomes and increase the usefulness of Social Return on Investment estimation in this area. Militaries should invest greater effort and funding in achieving, maintaining, and optimizing personnel health and performance. Promoting healthy diet behaviors should be prioritized as a cost-effective preventive action that supports productivity and performance, in comparison with the costs of remediating treatment. Conceptualizing the value of improving diet behaviors in monetary terms may refocus efforts on prevention rather than treatment.