Articles: treatment.
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Achondroplasia is a genetic skeletal condition that results in disproportionately short stature and medical complications throughout life. Infigratinib is an orally bioavailable FGFR1-3 selective tyrosine kinase inhibitor in development for achondroplasia. ⋯ The administration of oral infigratinib did not result in any apparent major safety signal and increased the annualized height velocity and z score and decreased the upper-to-lower body segment ratio at 18 months of treatment in cohort 5. (Funded by BridgeBio Pharma; PROPEL2 ClinicalTrials.gov number, NCT04265651.).
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Polycythemia vera (PV), a myeloproliferative neoplasm characterized by an increased red blood cell mass and increased risk of thrombosis, affects approximately 65 000 people in the US, with an annual incidence of 0.5 to 4.0 cases per 100 000 persons. ⋯ PV is a myeloproliferative neoplasm characterized by erythrocytosis and is almost universally associated with a JAK2 gene variant. PV is associated with an increased risk of arterial and venous thrombosis, hemorrhage, myelofibrosis, and acute myeloid leukemia. To decrease the risk of thrombosis, all patients with PV should be treated with aspirin and therapeutic phlebotomy to maintain a hematocrit of less than 45%. Cytoreductive therapies, such as hydroxyurea or interferon, are recommended for patients at high risk of thrombosis.
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Rural America faces an alarming obesity crisis, with residents experiencing significantly higher rates of obesity due to socioeconomic disparities, limited access to healthcare, and structural challenges such as food deserts and insufficient healthcare infrastructure. This perspective addresses these pressing issues by proposing targeted, evidence-based interventions to reduce obesity in rural communities. ⋯ R. 1577, the Treat and Reduce Obesity Act, to alleviate financial barriers to treatment, including intensive behavioral therapy and pharmacotherapy; and (3) leveraging community-based programs, including the National Rural Obesity and Chronic Disease Initiative, the CDC's High Obesity Program, and the Delta Body and Soul initiative, to improve access to healthy foods and promote physical activity through local collaborations, education, and infrastructure enhancements. By implementing these comprehensive strategies, we aim to make obesity treatments and healthy lifestyle choices more accessible, ultimately reducing obesity rates, improving health outcomes, and enhancing the overall quality of life for rural residents across the USA.