Articles: acute-pain.
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To determine if postoperative gabapentin administration is associated with decreased opioid consumption or pain scores following cesarean delivery in women on chronic buprenorphine. ⋯ In parturients receiving chronic buprenorphine, inclusion of gabapentin in a multimodal analgesic regimen was not associated with lower opioid consumption or pain scores during the first 72 h after cesarean delivery. Prospective randomized studies are needed to confirm these findings.
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Nociceptive and pruriceptive neurons in the dorsal root ganglia (DRG) convey sensations of pain and itch to the spinal cord, respectively. One subtype of mature DRG neurons, comprising 6% to 8% of neurons in the ganglia, is responsible for sensing mediators of acute itch and atopic dermatitis, including the cytokine IL-31. How itch-sensitive (pruriceptive) neurons are specified is unclear. ⋯ Accordingly, lentiviral re-expression of TMEM184B in mutant embryonic neurons restores Wnt signatures. Together, these data demonstrate that TMEM184B promotes adult somatosensation through developmental Wnt signaling and promotion of proper pruriceptive gene expression. Our data illuminate a new key regulatory step in the processes controlling the establishment of diversity in the somatosensory system.
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Bromine is a water-soluble, severely toxic element. It leads to tissue injury by causing the release of radical oxygen species from mucosal membranes. Redness or brownish discoloration of the skin, pain, measles-like rash, vesicles, blisters, pustules, furuncles, burns, and ulcers may be seen in the acute phase. ⋯ Although bromine burn is rare, it causes severe damage to the skin, and injury starts insidiously without causing a visible skin reaction at the beginning. Irrigation with plenty of water in the early period is critically important in reducing the severity of the injury. Key Words: Bromine, Burn, Skin, Radical oxygen species.