Articles: sepsis.
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Sepsis is a life-threatening condition driven by a dysregulated immune response to infection. Identifying the genetic factors underlying sepsis pathogenesis remains a major challenge in developing effective treatments. ⋯ BEND7 was identified as a platelet-specific gene involved in immune regulation during sepsis. Targeting BEND7-positive platelets may present new therapeutic opportunities in sepsis management.
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Observational Study
Development and performance evaluation of a clinical prediction model for sepsis risk in burn patients.
Sepsis is a common and severe complication in burn patients and remains one of the leading causes of mortality. This retrospective study aimed to develop a predictive model for the risk of in-hospital sepsis among burn patients treated at Guangzhou Red Cross Hospital between January 2022 and January 2024, with the goal of improving clinical outcomes through early prevention based on risk stratification. A total of 302 eligible patients were randomly divided into training and validation cohorts in a 7:3 ratio for model development and validation, respectively. ⋯ The areas under the receiver operating characteristic curve were 0.875 and 0.861 for the training and validation cohorts, with Youden indexes of 0.634 and 0.600, respectively. The calibration curve and decision curve analysis demonstrated good predictive accuracy and clinical utility of the model. These findings suggest that our developed model exhibits robust predictive performance for the risk of in-hospital sepsis in burn patients, and early prevention strategies based on risk stratification may potentially improve clinical outcomes.
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Acute circulatory failure is critical in ICU patients. CO2-O2-derived indices including the central venous-to-arterial CO2 difference (P(v-a)CO2 gap) and the P(v-a)CO2 gap/Ca-vO2 ratio are markers for global metabolic demand and tissue hypoxia. ⋯ Algorithm-based resuscitation using CO2-O2-derived indices did not improve lactate clearance or clinical outcomes compared to standard care. Further research needed to identify specific patient subgroups who may benefit from this approach.
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Sepsis-associated acute kidney injury (SA-AKI) is common and associated with poor outcomes in critically ill patients. Acetaminophen is often used as an antipyretic and analgesic drug, but the association of acetaminophen use with mortality and recovery of renal function in SA-AKI patients remain unclear. We aimed to investigate the association between acetaminophen use and outcomes in SA-AKI patients. ⋯ Acetaminophen use is associated with decreased mortality and improved renal recovery in SA-AKI patients.