Articles: sepsis.
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Low dose ATP-MgCl2 is reported to cause selective pulmonary vasodilation during hypoxic and thromboxane mimetic-induced constriction. In addition, it has been shown to increase cardiac output and improve cellular function during circulatory shock. Based on these properties we hypothesized that ATP-MgCl2 might ameliorate the cardiopulmonary manifestations of sepsis secondary to group B streptococci (GBS). ⋯ Also dynamic lung compliance was higher (p < 0.001) and pulmonary airway resistance lower (p < 0.001) in treated animals. Median survival in control animals was 153 min, whereas all treated animals survived to 240 min (p < 0.001). These data demonstrate that ATP-MgCl2 ameliorates the deleterious cardiopulmonary manifestations of GBS sepsis and results in improved survival in a young animal model.
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Anasthesiol Intensivmed Notfallmed Schmerzther · Apr 1996
Review[Is infection and septic shock caused by a global oxygen deficiency? An overview in 2 parts. 1: Infection and correlation between DO2 and VO2].
A global hypoxia resulting in an oxygen debt is assumed to be present in patients who suffer from the different stages and degrees of sepsis including septic shock and ARDS. As a consequence, the therapeutic concept of optimal values for cardiac output and oxygen delivery for these patients was proposed. This article reviews the literature with the objective of determining whether investigations dealing with oxygen delivery and consumption and with the plasma lactate concentration support the idea of the global hypoxia in septic patients. ⋯ The dogmatic proposal to increase cardiac output and oxygen delivery to certain levels cannot be sustained. However, regional hypoperfusion (e.g., of the splanchnic vascular bed) cannot be excluded. New approaches like gastric mucosal tonometry, measurement of splanchnic blood flow, and determination of regional metabolism are currently under investigation.
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Int J Obstet Anesth · Apr 1996
Critically ill parturient women and admission to intensive care: a 5-year review.
Thirty-nine parturient women were admitted to a general intensive care unit (ICU) from April 1989 to March 1994 and of these four were readmitted (total 43 admissions). Twelve women were admitted to the obstetric unit from peripheral hospitals in different regions, but no requirement for intensive care was perceived on referral. Six women were transfered directly into the intensive care unit from different hospitals in the region. ⋯ A multidisciplinary approach to management is practised and specialist interventions included haemofiltration and haemodialysis (18%) and radiological arterial embolisation (10%). Ventilatory and inotropic support were given in 38% and 41% of patients respectively. Only one patient died on the intensive care unit, this was from multiorgan failure secondary to sepsis.
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Critical care medicine · Apr 1996
Comparative StudyEarly prediction of outcome in score-identified, postcardiac surgical patients at high risk for sepsis, using soluble tumor necrosis factor receptor-p55 concentrations.
To investigate the prognostic value of increased serum concentrations of soluble tumor necrosis factor (TNF) receptors in patients at high risk for sepsis. ⋯ This study suggest that increased soluble TNF receptor-p55 concentrations in the serum of postcardiac surgical patients allow earlier prognostication of subsequent hospital course than APACHE II scores alone. This study further suggests that the combination of physiologic scores and cytokine receptor measurements could improve the predictive power of early postoperative risk stratification.