Articles: postoperative-complications.
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Clinical Trial Controlled Clinical Trial
[The influence of hydroxyethyl starch on postoperative alterations of blood coagulation (author's transl)].
The influence of hydroxyethyl starch (HES) on postoperative hypercoagulaemia was examined in a double blind study. One group of 10 patients received 500 ml HES during surgery and on the following three days. ⋯ In some respects, hypercoagulaemia was significantly diminished in the HES-group. The diminution could, however, be mainly explained by the diluting effect of the plasma expander.
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The transformation of lymphocytes in response to phytohemagglutinin stimulation was investigated in 77 patients undergoind anesthesia with and without coincident surgical operation. A depression of lymphocyte transformation apparent immediately following major operations was related primarily to the extent of tissue trauma and not to the anesthetic agent or technique. No depression of lymphocyte transformation followed anesthesia for treatment of pain or for minor operations. ⋯ The leukocyte count did not increase after comparable operations performed with regional anesthesia. Postoperative depression of lymphocyte transformation is primarily due to nonspecific stress, perhaps because of associated sympathetic and adrenocortical stimulation. The depressant effect of anesthesia alone is minimal.