Articles: opioid.

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• Critical care medicine · Dec 2023

  Editorial Comment

  Buprenorphine: Its Emerging Role as a Strategy to Reduce Full Opioid Agonist Use in the ICU.

  no abstract available

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• Br J Anaesth · Dec 2023

  Comment Letter

  Impact of female sex on anaesthetic awareness, depth, and emergence. Comment on Br J Anaesth 2023; 131: 510-22.

  no abstract available

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• J Gen Intern Med · Dec 2023

  Editorial

  Mobilizing Primary Care Against the Opioid Crisis in the Post X-Waiver Era.

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• Ann. Intern. Med. · Dec 2023

  Comment

  In symptomatic adults undergoing high-resolution manometry, long-term opioid use was linked to esophageal dysmotility.

  Niu C, Zhang J, Bapaye J, et al. Systematic review with meta-analysis: chronic opioid use is associated with esophageal dysmotility in symptomatic patients. Am J Gastroenterol. 18 Aug 2023. [Epub ahead of print]. 37463432.

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• Anesthesiology · Dec 2023

  Randomized Controlled Trial

  Neurocognitive effect of biased µ-opioid receptor agonist oliceridine, a utility function analysis and comparison with morphine.

  Oliceridine (Olinvyk) is a μ-opioid receptor agonist that in contrast to conventional opioids preferentially engages the G-protein-coupled signaling pathway. This study was designed to determine the utility function of oliceridine versus morphine based on neurocognitive tests and cold pressor test. ⋯ These data indicate that over the clinical concentration range, oliceridine is an analgesic with a favorable safety profile over morphine when considering analgesia and neurocognitive function.

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