Articles: cations.
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Endovascular therapy is favored for ruptured intracranial aneurysms in the elderly. However, poor accessibility to the aneurysm through the parent artery and use of local anesthesia in this age group may predispose to intraprocedural complications. ⋯ Increasing age was correlated with poor accessibility of the guiding catheter in endovascular embolization of ruptured intracranial aneurysms. Distally located aneurysms treated through a low-positioned guiding catheter and use of local anesthesia increased the risk of procedure-related rupture.
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The crucial role of the endothelium in sepsis is well recognized. The aim of this study was to establish a flow model to study endothelial activation induced by lipopolysaccharide (LPS) or by plasma from septic patients. We report on the application of this model to assess the effect of adsorbent-based cytokine modulation on endothelial activation. ⋯ The flow model allows to study endothelial activation and the interaction of activated endothelial cells with blood cells. Cytokine modulation with PS-DVB polymers reduced endothelial activation and decreased monocyte adhesion.(Figure is included in full-text article.).
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Local drug application is used to avoid systemic side effects. We analysed whether locally applied Iloprost (PGI2-analogue) or Nitroglycerin (NO-donor) influence gastric mucosal perfusion (μflow) and oxygenation (μHbO2) during physiological and haemorrhagic conditions. ⋯ Strategischer Forschungsfonds.
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There is increasing evidence for the existence of a Trauma-Induced Secondary Cardiac Injury (TISCI), which, with resultant cardiac dysfunction, contributes to late mortality and morbidity in severely injured patients. The aim of my study was to demonstrate that cardiomyocyte injury induced by trauma, reflected by H-FABP, correlates with echocardiographic markers of cardiac function. ⋯ This study has demonstrated the dose-dependent relationship of H-FABP release with the severity of trauma haemorrhage and measured cardiac function. The release of H-FABP from the myocardium into the circulation correlates with the severity of the haemodynamic challenge with the highest values correlating with the lowest MAP (Fig. 1) and cardiac output (Fig. 2). The functional data presented here strengthens the case for H-FABP as a useful biomarker in the identification and stratification of TISCI.(Figure is included in full-text article.)(Figure is included in full-text article.).