Articles: pain.
-
Clinical Trial Controlled Clinical Trial
Relative analgesic potency of oral zomepirac and intramuscular morphine in cancer patients with postoperative pain.
A twin crossover assay of oral zomepirac and intramuscular morphine was completed in 159 cancer patients with postoperative pain. Zomepirac was a surprisingly effective oral analgesic in these patients, 100 mg orally being roughly equivalent to 16 mg intramuscular morphine. ⋯ Side effect occurrence was roughly in the same range for both drugs, with drowsiness, nausea, dry mouth, and feelings of weakness being observed after both drugs while sweating was observed more frequently after zomepirac. The assay further provided a demonstration of the effectiveness of the twin crossover design as a clinical assay method, providing increased sensitivity of crossover data in a patient population available for only a limited number of study treatments.
-
Comparative Study Clinical Trial
Clinical comparison of zomepirac with pentazocine in the treatment of postoperative pain.
-
Comparative Study
A psychophysical analysis of experimential factors that selectively influence the affective dimension of pain.
A psychophysical analysis was made of experiential factors that influence the affective but not the sensory-discriminative dimension of pain. Seven subjects made cross-modality matching responses to several dimensions of their experience. Before each stimulus, they matched line lengths to their experienced desire to avoid pain (significance) and to their perceived likelihood of avoiding it (expectation). ⋯ In the other session, they simply focused on the pleasantness or unpleasantness of each sensation as it was experienced (affect-process responses). All subjects' affect-result responses were more positive (or less unpleasant) than affect-process responses. All of these results underscore the critical influence of expectations and the manner in which one evaluates sensations on affective responses to noxious stimulation.
-
Comparative Study Clinical Trial
A controlled repeat-dose comparison of zomepirac and clometacin in pain after plastic surgery.