Articles: ninos.
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Growing evidence demonstrates that a number of clinical disorders may be related to genetic defects in telomere replication and extension. Overall, these syndromes are referred to as "telomeropathies" or "telomere disorders/syndromes"; they are increasingly being identified. In adulthood, idiopathic pulmonary fibrosis (IPF) is the most common symptom of telomeropathy. ⋯ In a cohort of patients addressed to lung transplantation, authors were able to demonstrate that subclinical bone marrow and liver abnormalities can be seen in patients with interstitial lung disease (ILD) and short telomeres, in some cases in the absence of clinically significant abnormalities in peripheral blood count and liver function tests. This observation sustains the rationale for further studies aimed to validate telomere length testing as a useful parameter as part of the evaluation for transplant candidacy. A deeper clarification of the complex link between IPF and short telomeres and telomeropathies is required for a new ILD classification, aimed to a fully personalized approach to the disease.
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Asthma is a serious global health problem affecting all age groups, with global prevalence. Although controller medications are usually highly-effective asthma treatments, patient adherence remains poor, and under-use is associated with greater health resource use, morbidity, and mortality. ⋯ The results suggested that inhaler reminders may represent an effective strategy for improving adherence in primary care compared with a behavioral intervention or usual care, although this may not be reflected in differences in levels of asthma control. Studies in larger population are needed in order to test the efficacy of available technology on asthma outcomes in all age stages.
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Historical Article
Correction: History and Future of Treatment of Hypothyroidism.
There is an error in a recent article. The last sentence of the section titled "L-Thyroxine Monotherapy Fails to Restore All Markers of Hypothyroidism" should read "new technology is needed to allow for steady delivery of L-triiodothyronine" (it currently reads "… for steady delivery of L-thyroxine"). This has been corrected in the online version.
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Cochrane Db Syst Rev · Feb 2016
ReviewStrategies designed to help healthcare professionals to recruit participants to research studies.
Identifying and approaching eligible participants for recruitment to research studies usually relies on healthcare professionals. This process is sometimes hampered by deliberate or inadvertent gatekeeping that can introduce bias into patient selection. ⋯ There is no strong evidence for any single strategy to help healthcare professionals to recruit participants in research studies. Additional visits or information did not appear to increase recruitment by healthcare professionals. The most promising strategies appear to be those with a dedicated resource (e.g. a clinical recruiter or automated alert system) for identifying suitable participants that reduced the demand on healthcare professionals, but these were assessed in studies at high risk of bias.
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Asthma is a serious global health problem affecting all age groups, with global prevalence. Although controller medications are usually highly effective asthma treatments, patient adherence remains poor, and under-use is associated with greater health resource use, morbidity, and mortality. ⋯ The results suggested that inhaler reminders may represent an effective strategy for improving adherence in primary care compared with a behavioral intervention or usual care, although this may not be reflected in differences in levels of asthma control. Studies in larger population are needed in order to test the efficacy of available technology on asthma outcomes in all age stages.