Articles: ninos.
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The goals of this study were to define the endpoints of pain research that are important to patients with chronic pain and to identify clinical and demographic variables that are associated with patients' choices of endpoints. ⋯ These data suggest that empirical research can provide data to guide the choice of endpoints in clinical studies of pain interventions.
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The role of physician variability in pain management is unknown. ⋯ Lower expectations for relief and less satisfaction in its management may contribute to the undertreatment of chronic pain. Perceptions of regulatory scrutiny may contribute to suboptimal pain management. These preliminary data highlight physician variability in pain decision making while providing insights into educational needs.
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The purpose of this investigation was to study specifically those cases of sudden death out-of-hospital in the Reykjavik area that were due to non-cardiac causes the last 13 years, from January 1987 to December 31, 1999. ⋯ In this study the data were reported in accordance with the Utstein protocol and therefore drug intoxication and suicide are not grouped together. However, most if not all cases of drug intoxication appear to have occurred in an attempt of suicide. Except for cardiac disease drug intoxication and suicides were together the most common causes of sudden death out-of-hospital in those instances attended by the crew of the emergency ambulance. The results of resuscitation attempts are much worse when the cause for sudden death is non-cardiac. Survival was relatively best in cases of "suffocation" or "drowning".
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The incidence of prostate cancer is related to aging. Its increase in the last 10 years, varies from country to country and according to ethnic group, with its greatest incidence among African-American males and the least among Asian males. Only two risk factors have thus far been clearly established for prostate cancer: familial aggregation and ethnic origin. ⋯ Using this transmission model and linkage analysis, three predisposing loci on chromosome 1: HPC-1 (hereditary prostate cancer 1: 1q24-25), PCaP (predisposing for prostate cancer: 1q42-43) and CAPB (predisposing for prostate and brain tumor: 1p36) and one locus on chromosome 20 (HPC20: 20q13) have been described. Moreover, X-linked transmission has been suggested and related to another predisposing gene locus: HPCX (Xq27-28). It is possible that a large proportion of familial prostate cancer is due not to segregation of a few major gene mutations transmitted according to a monogenic inheritance, but rather to familial sharing of alleles at many loci, each contributing to a small increase in cancer risk.